mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling

mtDNA mutagenesis in somatic stem cells leads to their dysfunction and to progeria in mouse. The mechanism was proposed to involve modification of reactive oxygen species (ROS)/redox signaling. We studied the effect of mtDNA mutagenesis on reprogramming and stemness of pluripotent stem cells (PSCs)...

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Detalles Bibliográficos
Autores principales: Hämäläinen, Riikka H., Ahlqvist, Kati J., Ellonen, Pekka, Lepistö, Maija, Logan, Angela, Otonkoski, Timo, Murphy, Michael P., Suomalainen, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509707/
https://www.ncbi.nlm.nih.gov/pubmed/26027936
http://dx.doi.org/10.1016/j.celrep.2015.05.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509707/
https://www.ncbi.nlm.nih.gov/pubmed/26027936
http://dx.doi.org/10.1016/j.celrep.2015.05.009

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