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Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses
Human adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. From 2005 to 2013 a prospective study was conducted on children admitted with acute respiratory infections. Specim...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509737/ https://www.ncbi.nlm.nih.gov/pubmed/26147465 http://dx.doi.org/10.1371/journal.pone.0132162 |
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author | Calvo, Cristina García-García, María Luz Sanchez-Dehesa, Rosa Román, Cristina Tabares, Ana Pozo, Francisco Casas, Inmaculada |
author_facet | Calvo, Cristina García-García, María Luz Sanchez-Dehesa, Rosa Román, Cristina Tabares, Ana Pozo, Francisco Casas, Inmaculada |
author_sort | Calvo, Cristina |
collection | PubMed |
description | Human adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. From 2005 to 2013 a prospective study was conducted on children admitted with acute respiratory infections. Specimens of nasopharyngeal aspirate were taken for virological study by PCR and clinical data was recorded. HAdV specimens were genotyped. Frequency and clinical course of HAdV infections were compared with RSV, rhinovirus (RV), human bocavirus (HBoV) and influenza in the same population. HAdV was detected in 403 cases of 2371 confirmed viral infections (17.2%) , of which 154 were single virus infections (38%). We genotyped 154 HAdVs. The most frequent genotypes were HAdV-3 (24%), HAdV-6 (21%), and HAdV-5 (20%). A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%). The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity. Adenovirus single infections were compared with single infections of 598 RSV, 494 RV, 83 influenza and 78 HBoV. Significant clinical differences were found between HAdV, RSV and RV infections. |
format | Online Article Text |
id | pubmed-4509737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45097372015-07-24 Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses Calvo, Cristina García-García, María Luz Sanchez-Dehesa, Rosa Román, Cristina Tabares, Ana Pozo, Francisco Casas, Inmaculada PLoS One Research Article Human adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. From 2005 to 2013 a prospective study was conducted on children admitted with acute respiratory infections. Specimens of nasopharyngeal aspirate were taken for virological study by PCR and clinical data was recorded. HAdV specimens were genotyped. Frequency and clinical course of HAdV infections were compared with RSV, rhinovirus (RV), human bocavirus (HBoV) and influenza in the same population. HAdV was detected in 403 cases of 2371 confirmed viral infections (17.2%) , of which 154 were single virus infections (38%). We genotyped 154 HAdVs. The most frequent genotypes were HAdV-3 (24%), HAdV-6 (21%), and HAdV-5 (20%). A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%). The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity. Adenovirus single infections were compared with single infections of 598 RSV, 494 RV, 83 influenza and 78 HBoV. Significant clinical differences were found between HAdV, RSV and RV infections. Public Library of Science 2015-07-06 /pmc/articles/PMC4509737/ /pubmed/26147465 http://dx.doi.org/10.1371/journal.pone.0132162 Text en © 2015 Calvo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Calvo, Cristina García-García, María Luz Sanchez-Dehesa, Rosa Román, Cristina Tabares, Ana Pozo, Francisco Casas, Inmaculada Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses |
title | Eight Year Prospective Study of Adenoviruses Infections in
Hospitalized Children. Comparison with Other Respiratory Viruses |
title_full | Eight Year Prospective Study of Adenoviruses Infections in
Hospitalized Children. Comparison with Other Respiratory Viruses |
title_fullStr | Eight Year Prospective Study of Adenoviruses Infections in
Hospitalized Children. Comparison with Other Respiratory Viruses |
title_full_unstemmed | Eight Year Prospective Study of Adenoviruses Infections in
Hospitalized Children. Comparison with Other Respiratory Viruses |
title_short | Eight Year Prospective Study of Adenoviruses Infections in
Hospitalized Children. Comparison with Other Respiratory Viruses |
title_sort | eight year prospective study of adenoviruses infections in
hospitalized children. comparison with other respiratory viruses |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509737/ https://www.ncbi.nlm.nih.gov/pubmed/26147465 http://dx.doi.org/10.1371/journal.pone.0132162 |
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