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Age-dependent therapeutic effects of liver X receptor-α activation in murine polymicrobial sepsis

The severity of sepsis is significantly affected by advanced age; however, age-dependent molecular mechanisms of this susceptibility are unknown. Nuclear liver X receptor-α (LXRα) is a regulator of lipid metabolism with associated anti-inflammatory properties. Here, we investigated the role of LXRα...

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Detalles Bibliográficos
Autores principales:	Botez, Gabriela, Piraino, Giovanna, Hake, Paul W, Ledford, John R, O’Connor, Michael, Cook, James A, Zingarelli, Basilia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509881/ https://www.ncbi.nlm.nih.gov/pubmed/25956304 http://dx.doi.org/10.1177/1753425915569367

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