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Prediction error and trace dominance determine the fate of fear memories after post-training manipulations

Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization–reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, litt...

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Autores principales: Alfei, Joaquín M., Ferrer Monti, Roque I., Molina, Victor A., Bueno, Adrián M., Urcelay, Gonzalo P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509917/
https://www.ncbi.nlm.nih.gov/pubmed/26179232
http://dx.doi.org/10.1101/lm.038513.115
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author Alfei, Joaquín M.
Ferrer Monti, Roque I.
Molina, Victor A.
Bueno, Adrián M.
Urcelay, Gonzalo P.
author_facet Alfei, Joaquín M.
Ferrer Monti, Roque I.
Molina, Victor A.
Bueno, Adrián M.
Urcelay, Gonzalo P.
author_sort Alfei, Joaquín M.
collection PubMed
description Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization–reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes.
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spelling pubmed-45099172016-08-01 Prediction error and trace dominance determine the fate of fear memories after post-training manipulations Alfei, Joaquín M. Ferrer Monti, Roque I. Molina, Victor A. Bueno, Adrián M. Urcelay, Gonzalo P. Learn Mem Research Paper Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization–reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes. Cold Spring Harbor Laboratory Press 2015-08 /pmc/articles/PMC4509917/ /pubmed/26179232 http://dx.doi.org/10.1101/lm.038513.115 Text en © 2015 Alfei et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Paper
Alfei, Joaquín M.
Ferrer Monti, Roque I.
Molina, Victor A.
Bueno, Adrián M.
Urcelay, Gonzalo P.
Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_full Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_fullStr Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_full_unstemmed Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_short Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_sort prediction error and trace dominance determine the fate of fear memories after post-training manipulations
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509917/
https://www.ncbi.nlm.nih.gov/pubmed/26179232
http://dx.doi.org/10.1101/lm.038513.115
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