Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells

Duplication of the genome in mammalian cells occurs in a defined temporal order referred to as its replication-timing (RT) program. RT changes dynamically during development, regulated in units of 400–800 kb referred to as replication domains (RDs). Changes in RT are generally coordinated with trans...

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Detalles Bibliográficos
Autores principales: Rivera-Mulia, Juan Carlos, Buckley, Quinton, Sasaki, Takayo, Zimmerman, Jared, Didier, Ruth A., Nazor, Kristopher, Loring, Jeanne F., Lian, Zheng, Weissman, Sherman, Robins, Allan J., Schulz, Thomas C., Menendez, Laura, Kulik, Michael J., Dalton, Stephen, Gabr, Haitham, Kahveci, Tamer, Gilbert, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509994/
https://www.ncbi.nlm.nih.gov/pubmed/26055160
http://dx.doi.org/10.1101/gr.187989.114

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