Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice

The germline mutation rate is an important parameter that affects the amount of genetic variation and the rate of evolution. However, neither the rate of germline mutations in laboratory mice nor the biological significance of the mutation rate in mammalian populations is clear. Here we studied geno...

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Detalles Bibliográficos
Autores principales: Uchimura, Arikuni, Higuchi, Mayumi, Minakuchi, Yohei, Ohno, Mizuki, Toyoda, Atsushi, Fujiyama, Asao, Miura, Ikuo, Wakana, Shigeharu, Nishino, Jo, Yagi, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509997/
https://www.ncbi.nlm.nih.gov/pubmed/26129709
http://dx.doi.org/10.1101/gr.186148.114

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