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Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort

We report a novel high-throughput method to empirically quantify individual-specific regulatory element activity at the population scale. The approach combines targeted DNA capture with a high-throughput reporter gene expression assay. As demonstration, we measured the activity of more than 100 puta...

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Detalles Bibliográficos
Autores principales:	Vockley, Christopher M., Guo, Cong, Majoros, William H., Nodzenski, Michael, Scholtens, Denise M., Hayes, M. Geoffrey, Lowe, William L., Reddy, Timothy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510004/ https://www.ncbi.nlm.nih.gov/pubmed/26084464 http://dx.doi.org/10.1101/gr.190090.115

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