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Current Concepts in the Management of Rheumatoid Hand
Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a T cell-driven autoimmune process, which majorly involves the diarthrodial joints. It affects 1% of the US population, and approximately 70% of patients with RA develop pathologies of the hand, especially of the metacarpophalange...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510119/ https://www.ncbi.nlm.nih.gov/pubmed/26236341 http://dx.doi.org/10.1155/2015/648073 |
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author | Longo, Umile Giuseppe Petrillo, Stefano Denaro, Vincenzo |
author_facet | Longo, Umile Giuseppe Petrillo, Stefano Denaro, Vincenzo |
author_sort | Longo, Umile Giuseppe |
collection | PubMed |
description | Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a T cell-driven autoimmune process, which majorly involves the diarthrodial joints. It affects 1% of the US population, and approximately 70% of patients with RA develop pathologies of the hand, especially of the metacarpophalangeal joints (MCP). Furthermore, also the extensor and flexor tendons of the fingers are frequently involved. The first line of treatment should be conservative. Three general classes of drugs are currently available for RA: nonsteroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying antirheumatic drugs (DMARDs). Encouraging results have been obtained using DMARDs. However, when severe deformities occur or when patients are unresponsive to medical management and injections therapy, surgical intervention should be performed to relieve pain and restore function. Several surgical options have been described for the management of MCP joint deformities, including soft tissue procedures, arthrodesis, and prosthetic replacement. Tendons ruptures are generally managed with tendon transfer surgery, while different surgical procedures are available to treat fingers deformities. The aim of the present review is to report the current knowledge in the management of MCP joint deformities, as well as tendons damage and fingers deformities, in patients with RA. |
format | Online Article Text |
id | pubmed-4510119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45101192015-08-02 Current Concepts in the Management of Rheumatoid Hand Longo, Umile Giuseppe Petrillo, Stefano Denaro, Vincenzo Int J Rheumatol Review Article Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a T cell-driven autoimmune process, which majorly involves the diarthrodial joints. It affects 1% of the US population, and approximately 70% of patients with RA develop pathologies of the hand, especially of the metacarpophalangeal joints (MCP). Furthermore, also the extensor and flexor tendons of the fingers are frequently involved. The first line of treatment should be conservative. Three general classes of drugs are currently available for RA: nonsteroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying antirheumatic drugs (DMARDs). Encouraging results have been obtained using DMARDs. However, when severe deformities occur or when patients are unresponsive to medical management and injections therapy, surgical intervention should be performed to relieve pain and restore function. Several surgical options have been described for the management of MCP joint deformities, including soft tissue procedures, arthrodesis, and prosthetic replacement. Tendons ruptures are generally managed with tendon transfer surgery, while different surgical procedures are available to treat fingers deformities. The aim of the present review is to report the current knowledge in the management of MCP joint deformities, as well as tendons damage and fingers deformities, in patients with RA. Hindawi Publishing Corporation 2015 2015-07-08 /pmc/articles/PMC4510119/ /pubmed/26236341 http://dx.doi.org/10.1155/2015/648073 Text en Copyright © 2015 Umile Giuseppe Longo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Longo, Umile Giuseppe Petrillo, Stefano Denaro, Vincenzo Current Concepts in the Management of Rheumatoid Hand |
title | Current Concepts in the Management of Rheumatoid Hand |
title_full | Current Concepts in the Management of Rheumatoid Hand |
title_fullStr | Current Concepts in the Management of Rheumatoid Hand |
title_full_unstemmed | Current Concepts in the Management of Rheumatoid Hand |
title_short | Current Concepts in the Management of Rheumatoid Hand |
title_sort | current concepts in the management of rheumatoid hand |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510119/ https://www.ncbi.nlm.nih.gov/pubmed/26236341 http://dx.doi.org/10.1155/2015/648073 |
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