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Current Concepts in the Management of Rheumatoid Hand

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a T cell-driven autoimmune process, which majorly involves the diarthrodial joints. It affects 1% of the US population, and approximately 70% of patients with RA develop pathologies of the hand, especially of the metacarpophalange...

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Autores principales: Longo, Umile Giuseppe, Petrillo, Stefano, Denaro, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510119/
https://www.ncbi.nlm.nih.gov/pubmed/26236341
http://dx.doi.org/10.1155/2015/648073
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author Longo, Umile Giuseppe
Petrillo, Stefano
Denaro, Vincenzo
author_facet Longo, Umile Giuseppe
Petrillo, Stefano
Denaro, Vincenzo
author_sort Longo, Umile Giuseppe
collection PubMed
description Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a T cell-driven autoimmune process, which majorly involves the diarthrodial joints. It affects 1% of the US population, and approximately 70% of patients with RA develop pathologies of the hand, especially of the metacarpophalangeal joints (MCP). Furthermore, also the extensor and flexor tendons of the fingers are frequently involved. The first line of treatment should be conservative. Three general classes of drugs are currently available for RA: nonsteroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying antirheumatic drugs (DMARDs). Encouraging results have been obtained using DMARDs. However, when severe deformities occur or when patients are unresponsive to medical management and injections therapy, surgical intervention should be performed to relieve pain and restore function. Several surgical options have been described for the management of MCP joint deformities, including soft tissue procedures, arthrodesis, and prosthetic replacement. Tendons ruptures are generally managed with tendon transfer surgery, while different surgical procedures are available to treat fingers deformities. The aim of the present review is to report the current knowledge in the management of MCP joint deformities, as well as tendons damage and fingers deformities, in patients with RA.
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spelling pubmed-45101192015-08-02 Current Concepts in the Management of Rheumatoid Hand Longo, Umile Giuseppe Petrillo, Stefano Denaro, Vincenzo Int J Rheumatol Review Article Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a T cell-driven autoimmune process, which majorly involves the diarthrodial joints. It affects 1% of the US population, and approximately 70% of patients with RA develop pathologies of the hand, especially of the metacarpophalangeal joints (MCP). Furthermore, also the extensor and flexor tendons of the fingers are frequently involved. The first line of treatment should be conservative. Three general classes of drugs are currently available for RA: nonsteroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying antirheumatic drugs (DMARDs). Encouraging results have been obtained using DMARDs. However, when severe deformities occur or when patients are unresponsive to medical management and injections therapy, surgical intervention should be performed to relieve pain and restore function. Several surgical options have been described for the management of MCP joint deformities, including soft tissue procedures, arthrodesis, and prosthetic replacement. Tendons ruptures are generally managed with tendon transfer surgery, while different surgical procedures are available to treat fingers deformities. The aim of the present review is to report the current knowledge in the management of MCP joint deformities, as well as tendons damage and fingers deformities, in patients with RA. Hindawi Publishing Corporation 2015 2015-07-08 /pmc/articles/PMC4510119/ /pubmed/26236341 http://dx.doi.org/10.1155/2015/648073 Text en Copyright © 2015 Umile Giuseppe Longo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Longo, Umile Giuseppe
Petrillo, Stefano
Denaro, Vincenzo
Current Concepts in the Management of Rheumatoid Hand
title Current Concepts in the Management of Rheumatoid Hand
title_full Current Concepts in the Management of Rheumatoid Hand
title_fullStr Current Concepts in the Management of Rheumatoid Hand
title_full_unstemmed Current Concepts in the Management of Rheumatoid Hand
title_short Current Concepts in the Management of Rheumatoid Hand
title_sort current concepts in the management of rheumatoid hand
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510119/
https://www.ncbi.nlm.nih.gov/pubmed/26236341
http://dx.doi.org/10.1155/2015/648073
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