Cargando…

Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs

An involvement of the immune system has been suggested in Rett syndrome (RTT), a devastating neurodevelopmental disorder related to oxidative stress, and caused by a mutation in the methyl-CpG binding protein 2 gene (MECP2) or, more rarely, cyclin-dependent kinase-like 5 (CDKL5). To date, it is uncl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leoncini, Silvia, De Felice, Claudio, Signorini, Cinzia, Zollo, Gloria, Cortelazzo, Alessio, Durand, Thierry, Galano, Jean-Marie, Guerranti, Roberto, Rossi, Marcello, Ciccoli, Lucia, Hayek, Joussef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510261/ https://www.ncbi.nlm.nih.gov/pubmed/26236424 http://dx.doi.org/10.1155/2015/421624

Ejemplares similares

Effects of ω-3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome
por: De Felice, Claudio, et al.
Publicado: (2013)

MECP2 Duplication Syndrome: Evidence of Enhanced Oxidative Stress. A Comparison with Rett Syndrome
por: Signorini, Cinzia, et al.
Publicado: (2016)

Effects of ω-3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome
por: Maffei, Silvia, et al.
Publicado: (2014)

Subclinical Inflammatory Status in Rett Syndrome
por: Cortelazzo, Alessio, et al.
Publicado: (2014)

Persistent Unresolved Inflammation in the Mecp2-308 Female Mutated Mouse Model of Rett Syndrome
por: Cortelazzo, Alessio, et al.
Publicado: (2017)

Beta-Actin Deficiency with Oxidative Posttranslational Modifications in Rett Syndrome Erythrocytes: Insights into an Altered Cytoskeletal Organization
por: Cortelazzo, Alessio, et al.
Publicado: (2014)

Circulating 4-F(4t)-Neuroprostane and 10-F(4t)-Neuroprostane Are Related to MECP2 Gene Mutation and Natural History in Rett Syndrome
por: Signorini, Cinzia, et al.
Publicado: (2021)

A Plasma Proteomic Approach in Rett Syndrome: Classical versus Preserved Speech Variant
por: Cortelazzo, Alessio, et al.
Publicado: (2013)

Protective role of mirtazapine in adult female Mecp2(+/−) mice and patients with Rett syndrome
por: Flores Gutiérrez, Javier, et al.
Publicado: (2020)

Isoprostanes and 4-Hydroxy-2-nonenal: Markers or Mediators of Disease? Focus on Rett Syndrome as a Model of Autism Spectrum Disorder
por: Signorini, Cinzia, et al.
Publicado: (2013)

Genes Related to Mitochondrial Functions, Protein Degradation, and Chromatin Folding Are Differentially Expressed in Lymphomonocytes of Rett Syndrome Patients
por: Pecorelli, Alessandra, et al.
Publicado: (2013)

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome
por: De Felice, Claudio, et al.
Publicado: (2014)

Redox Imbalance and Morphological Changes in Skin Fibroblasts in Typical Rett Syndrome
por: Signorini, Cinzia, et al.
Publicado: (2014)

Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations: An Unrecognized Triad in Classical Autism
por: Ciccoli, Lucia, et al.
Publicado: (2013)

Isoprostanoids in Clinical and Experimental Neurological Disease Models
por: Signorini, Cinzia, et al.
Publicado: (2018)

Inflammatory Lung Disease in Rett Syndrome
por: De Felice, Claudio, et al.
Publicado: (2014)

Breathing Abnormalities During Sleep and Wakefulness in Rett Syndrome: Clinical Relevance and Paradoxical Relationship With Circulating Pro-oxidant Markers
por: Leoncini, Silvia, et al.
Publicado: (2022)

Immune Dysfunction in Rett Syndrome Patients Revealed by High Levels of Serum Anti-N(Glc) IgM Antibody Fraction
por: Papini, Anna Maria, et al.
Publicado: (2014)

Revealing the Complexity of a Monogenic Disease: Rett Syndrome Exome Sequencing
por: Grillo, Elisa, et al.
Publicado: (2013)

Isoprostanoid Plasma Levels Are Relevant to Cerebral Adrenoleukodystrophy Disease
por: Signorini, Cinzia, et al.
Publicado: (2022)

Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with bone disease severity in Rett syndrome
por: Caffarelli, Carla, et al.
Publicado: (2020)

Altered gut microbiota in Rett syndrome
por: Strati, Francesco, et al.
Publicado: (2016)

In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment
por: Fahmi, Muhamad, et al.
Publicado: (2019)

Rett Syndrome and CDKL5 Deficiency Disorder: From Bench to Clinic
por: Kadam, Shilpa D., et al.
Publicado: (2019)

Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent traits and capacity to persist within the host
por: Strati, Francesco, et al.
Publicado: (2018)

Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome
por: Mangatt, Meghana, et al.
Publicado: (2016)

Rett Syndrome and MECP2 Duplication Syndrome: Disorders of MeCP2 Dosage
por: Collins, Bridget E, et al.
Publicado: (2022)

The relationship of Rett syndrome and MECP2 disorders to autism
por: Neul, Jeffrey Lorenz
Publicado: (2012)

Multimodal Neuroimaging in Rett Syndrome With MECP2 Mutation
por: Kong, Yu, et al.
Publicado: (2022)

Antiglycative Activity and RAGE Expression in Rett Syndrome
por: Cordone, Valeria, et al.
Publicado: (2019)

Altered Bone Status in Rett Syndrome
por: Pecorelli, Alessandra, et al.
Publicado: (2021)

Cardioprotective Effects of ω-3 PUFAs in Chronic Kidney Disease
por: Lee, Su Mi, et al.
Publicado: (2013)

Spectrum of MECP2 mutations in Vietnamese patients with RETT syndrome
por: Le Thi Thanh, Huong, et al.
Publicado: (2018)

Structural investigation of Rett-inducing MeCP2 mutations()
por: Spiga, Ottavia, et al.
Publicado: (2018)

Rett mutations attenuate phase separation of MeCP2
por: Fan, Chunyan, et al.
Publicado: (2020)

The Molecular Functions of MeCP2 in Rett Syndrome Pathology
por: Sharifi, Osman, et al.
Publicado: (2021)

MeCP2: The Genetic Driver of Rett Syndrome Epigenetics
por: Good, Katrina V., et al.
Publicado: (2021)

A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth
por: Van Name, Michelle A, et al.
Publicado: (2020)

Relevance of ω-6 GLA Added to ω-3 PUFAs Supplements for ADHD: A Narrative Review
por: D’Helft, Jelle, et al.
Publicado: (2022)

ω-3 PUFAs in the Prevention and Cure of Inflammatory, Degenerative, and Neoplastic Diseases
por: Cittadini, Achille, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4uev1cbj2ord4ggn50ncrki88f