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Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients
Cutaneous features manifest as a wide range of clinically significant, and in many cases disfiguring and debilitating components of lupus erythematosus (LE). While the definitive etiology is in question, multifactorial and polygenic causes are likely to be involved in the production of the character...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510375/ https://www.ncbi.nlm.nih.gov/pubmed/26217761 http://dx.doi.org/10.1016/j.dib.2015.02.024 |
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author | Dey-Rao, R. Sinha, A.A. |
author_facet | Dey-Rao, R. Sinha, A.A. |
author_sort | Dey-Rao, R. |
collection | PubMed |
description | Cutaneous features manifest as a wide range of clinically significant, and in many cases disfiguring and debilitating components of lupus erythematosus (LE). While the definitive etiology is in question, multifactorial and polygenic causes are likely to be involved in the production of the characteristic anti-nuclear autoantibody titers and immune cell infiltrates observed in chronic cutaneous LE (CCLE) [1–3]. There is significant overlap of patients with systemic and cutaneous manifestations of LE, which suggests shared pathways and genetic background between the two. We have employed genome-wide microarray technology along with pathway-based analyses to investigate transcriptional differences between lesional and non-lesional skin from CCLE patients to address existing gaps in knowledge regarding disease mechanisms in lupus [4]. |
format | Online Article Text |
id | pubmed-4510375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45103752015-07-27 Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients Dey-Rao, R. Sinha, A.A. Data Brief Data Article Cutaneous features manifest as a wide range of clinically significant, and in many cases disfiguring and debilitating components of lupus erythematosus (LE). While the definitive etiology is in question, multifactorial and polygenic causes are likely to be involved in the production of the characteristic anti-nuclear autoantibody titers and immune cell infiltrates observed in chronic cutaneous LE (CCLE) [1–3]. There is significant overlap of patients with systemic and cutaneous manifestations of LE, which suggests shared pathways and genetic background between the two. We have employed genome-wide microarray technology along with pathway-based analyses to investigate transcriptional differences between lesional and non-lesional skin from CCLE patients to address existing gaps in knowledge regarding disease mechanisms in lupus [4]. Elsevier 2015-04-18 /pmc/articles/PMC4510375/ /pubmed/26217761 http://dx.doi.org/10.1016/j.dib.2015.02.024 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Data Article Dey-Rao, R. Sinha, A.A. Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients |
title | Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients |
title_full | Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients |
title_fullStr | Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients |
title_full_unstemmed | Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients |
title_short | Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients |
title_sort | genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (ccle) patients |
topic | Data Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510375/ https://www.ncbi.nlm.nih.gov/pubmed/26217761 http://dx.doi.org/10.1016/j.dib.2015.02.024 |
work_keys_str_mv | AT deyraor genomewidetranscriptionalprofilingdatafromskinofchroniccutaneouslupuserythematosuscclepatients AT sinhaaa genomewidetranscriptionalprofilingdatafromskinofchroniccutaneouslupuserythematosuscclepatients |