Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice

Rapamycin extends lifespan and attenuates age-related pathologies in mice when administered through diet at 14 parts per million (PPM). Recently, we reported that daily intraperitoneal injection of rapamycin at 8 mg/kg attenuates mitochondrial disease symptoms and progression in the Ndufs4 knockout...

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Detalles Bibliográficos
Autores principales: Johnson, Simon C., Yanos, Melana E., Bitto, Alessandro, Castanza, Anthony, Gagnidze, Arni, Gonzalez, Brenda, Gupta, Kanav, Hui, Jessica, Jarvie, Conner, Johnson, Brittany M., Letexier, Nicolas, McCanta, Lanny, Sangesland, Maya, Tamis, Oliver, Uhde, Lauren, Van Den Ende, Alex, Rabinovitch, Peter S., Suh, Yousin, Kaeberlein, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510413/
https://www.ncbi.nlm.nih.gov/pubmed/26257774
http://dx.doi.org/10.3389/fgene.2015.00247

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