Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis

The global variations in the gene expression pattern of drug treated (½X) and laboratory evolved drug-resistant strains (2XR and 4XR) of Mycobacterium smegmatis were obtained and compared with the M. smegmatis mc(2) 155 (WT) strain. The genes exhibiting two-fold change and p-value <0.05 under the...

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Detalles Bibliográficos
Autores principales: Padiadpu, Jyothi, Baloni, Priyanka, Chandra, Nagasuma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510432/
https://www.ncbi.nlm.nih.gov/pubmed/26217786
http://dx.doi.org/10.1016/j.dib.2015.05.006
Descripción
Sumario:The global variations in the gene expression pattern of drug treated (½X) and laboratory evolved drug-resistant strains (2XR and 4XR) of Mycobacterium smegmatis were obtained and compared with the M. smegmatis mc(2) 155 (WT) strain. The genes exhibiting two-fold change and p-value <0.05 under the treated conditions have been considered as differentially expressed genes (DEGs). Overall, the numbers of DEGs observed are 1529 in ½X (596—up, 933—down), 1381 (899—up, 482—down) in 2XR and 716 in 4XR (267—up, 449—down) conditions. The data is publicly available through the GEO database with accession number GSE64132.

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