Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates

A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed. PAPM-lipids and PAPG-lipids conjugates were also synthesized for targeting drugs to receptors. A binding inhibition study of synthesized p-(d...

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Detalles Bibliográficos
Autores principales: Ahmad, Moghis U., Ali, Shoukath M., Ahmad, Ateeq, Sheikh, Saifuddin, Chen, Paul, Ahmad, Imran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510549/
https://www.ncbi.nlm.nih.gov/pubmed/26217802
http://dx.doi.org/10.1016/j.dib.2015.05.026
Descripción
Sumario:A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed. PAPM-lipids and PAPG-lipids conjugates were also synthesized for targeting drugs to receptors. A binding inhibition study of synthesized p-(dimethylamino butylamido) phenyl-α-d-mannopyranoside (1a) with Concanavalin A was performed using invertase enzyme. In addition, transfection of pSV-β-gal reporter gene with was investigated in A549 cells.

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