Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates

A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed. PAPM-lipids and PAPG-lipids conjugates were also synthesized for targeting drugs to receptors. A binding inhibition study of synthesized p-(d...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmad, Moghis U., Ali, Shoukath M., Ahmad, Ateeq, Sheikh, Saifuddin, Chen, Paul, Ahmad, Imran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510549/
https://www.ncbi.nlm.nih.gov/pubmed/26217802
http://dx.doi.org/10.1016/j.dib.2015.05.026
_version_ 1782382190301020160
author Ahmad, Moghis U.
Ali, Shoukath M.
Ahmad, Ateeq
Sheikh, Saifuddin
Chen, Paul
Ahmad, Imran
author_facet Ahmad, Moghis U.
Ali, Shoukath M.
Ahmad, Ateeq
Sheikh, Saifuddin
Chen, Paul
Ahmad, Imran
author_sort Ahmad, Moghis U.
collection PubMed
description A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed. PAPM-lipids and PAPG-lipids conjugates were also synthesized for targeting drugs to receptors. A binding inhibition study of synthesized p-(dimethylamino butylamido) phenyl-α-d-mannopyranoside (1a) with Concanavalin A was performed using invertase enzyme. In addition, transfection of pSV-β-gal reporter gene with was investigated in A549 cells.
format Online
Article
Text
id pubmed-4510549
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-45105492015-07-27 Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates Ahmad, Moghis U. Ali, Shoukath M. Ahmad, Ateeq Sheikh, Saifuddin Chen, Paul Ahmad, Imran Data Brief Data Article A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed. PAPM-lipids and PAPG-lipids conjugates were also synthesized for targeting drugs to receptors. A binding inhibition study of synthesized p-(dimethylamino butylamido) phenyl-α-d-mannopyranoside (1a) with Concanavalin A was performed using invertase enzyme. In addition, transfection of pSV-β-gal reporter gene with was investigated in A549 cells. Elsevier 2015-06-17 /pmc/articles/PMC4510549/ /pubmed/26217802 http://dx.doi.org/10.1016/j.dib.2015.05.026 Text en © 2015 Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Ahmad, Moghis U.
Ali, Shoukath M.
Ahmad, Ateeq
Sheikh, Saifuddin
Chen, Paul
Ahmad, Imran
Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates
title Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates
title_full Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates
title_fullStr Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates
title_full_unstemmed Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates
title_short Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates
title_sort carbohydrate mediated drug delivery: synthesis and characterization of new lipid-conjugates
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510549/
https://www.ncbi.nlm.nih.gov/pubmed/26217802
http://dx.doi.org/10.1016/j.dib.2015.05.026
work_keys_str_mv AT ahmadmoghisu carbohydratemediateddrugdeliverysynthesisandcharacterizationofnewlipidconjugates
AT alishoukathm carbohydratemediateddrugdeliverysynthesisandcharacterizationofnewlipidconjugates
AT ahmadateeq carbohydratemediateddrugdeliverysynthesisandcharacterizationofnewlipidconjugates
AT sheikhsaifuddin carbohydratemediateddrugdeliverysynthesisandcharacterizationofnewlipidconjugates
AT chenpaul carbohydratemediateddrugdeliverysynthesisandcharacterizationofnewlipidconjugates
AT ahmadimran carbohydratemediateddrugdeliverysynthesisandcharacterizationofnewlipidconjugates

Ejemplares similares