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Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats

AIMS: To evaluate whether pharmacological TLR4 inhibition protects against acute and chronic fat-induced insulin resistance in rats. MATERIALS AND METHODS: For the acute experiment, rats received a TLR4 inhibitor [TAK-242 or E5564 (2x5 mg/kg i.v. bolus)] or vehicle, and an 8-h Intralipid (20%, 8.5 m...

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Detalles Bibliográficos
Autores principales:	Zhang, Ning, Liang, Hanyu, Farese, Robert V., Li, Ji, Musi, Nicolas, Hussey, Sophie E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510579/ https://www.ncbi.nlm.nih.gov/pubmed/26196892 http://dx.doi.org/10.1371/journal.pone.0132575

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