Telomeric G-quadruplexes are a substrate and site of localization for human telomerase

It has been hypothesized that G-quadruplexes can sequester the 3′ end of the telomere and prevent it from being extended by telomerase. Here we purify and characterize stable, conformationally homogenous human telomeric G-quadruplexes, and demonstrate that human telomerase is able to extend parallel...

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Detalles Bibliográficos
Autores principales: Moye, Aaron L., Porter, Karina C., Cohen, Scott B., Phan, Tram, Zyner, Katherine G., Sasaki, Natsuki, Lovrecz, George O., Beck, Jennifer L., Bryan, Tracy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510649/
https://www.ncbi.nlm.nih.gov/pubmed/26158869
http://dx.doi.org/10.1038/ncomms8643

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