The 19-bp deletion polymorphism of dihydrofolate reductase (DHFR) and nonsyndromic cleft lip with or without cleft palate: evidence for a protective role

OBJECTIVE: Nonsyndromic cleft lip with or without cleft palate (NS-CL/P) are among the most common congenital birth defects worldwide. Several lines of evidence point to the involvement of folate, as well as folate metabolizing enzymes in risk reduction of orofacial clefts. Dihydrofolate reductase (...

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Detalles Bibliográficos
Autores principales: RAFIGHDOOST, Firoozeh, RAFIGHDOOST, Amir, RAFIGHDOOST, Houshang, RIGI-LADEZ, Mohammad-Ayoob, HASHEMI, Mohammad, ESKANDARI-NASAB, Ebrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Odontologia de Bauru da Universidade de São Paulo 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510661/
https://www.ncbi.nlm.nih.gov/pubmed/26221921
http://dx.doi.org/10.1590/1678-775720140473

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