Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA

Pseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouse Oct4 pseudogenes and demonstrate that the X-linked Oct4 pseudogene Oct4P4 critically impacts mouse embryonic stem cells (mESCs) self-renewal. Sense Oct4P4 transcri...

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Detalles Bibliográficos
Autores principales: Scarola, Michele, Comisso, Elisa, Pascolo, Rhena, Chiaradia, Riccardo, Maria Marion, Rosa, Schneider, Claudio, Blasco, Maria A., Schoeftner, Stefan, Benetti, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510692/
https://www.ncbi.nlm.nih.gov/pubmed/26158551
http://dx.doi.org/10.1038/ncomms8631

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