RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway

The RNA-binding protein RC3H1 (also known as ROQUIN) promotes TNFα mRNA decay via a 3′UTR constitutive decay element (CDE). Here we applied PAR-CLIP to human RC3H1 to identify ∼3,800 mRNA targets with >16,000 binding sites. A large number of sites are distinct from the consensus CDE and revealed...

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Detalles Bibliográficos
Autores principales: Murakawa, Yasuhiro, Hinz, Michael, Mothes, Janina, Schuetz, Anja, Uhl, Michael, Wyler, Emanuel, Yasuda, Tomoharu, Mastrobuoni, Guido, Friedel, Caroline C., Dölken, Lars, Kempa, Stefan, Schmidt-Supprian, Marc, Blüthgen, Nils, Backofen, Rolf, Heinemann, Udo, Wolf, Jana, Scheidereit, Claus, Landthaler, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510711/
https://www.ncbi.nlm.nih.gov/pubmed/26170170
http://dx.doi.org/10.1038/ncomms8367

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