Negative feedback circuit for toll like receptor-8 activation in human embryonic Kidney 293 using outer membrane vesicle delivered bi-specific siRNA

BACKGROUND: TLR8 assists in antiviral approach by producing Type 1 INF via MyD88 dependent IRF7 pathway. However, over expression of INFα/β molecule poses threat by developing tolerance in chronic infection cases and enhancing inflammatory response. Here we report a bi-specific siRNA based complex w...

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Detalles Bibliográficos
Autores principales: Adhikari, Anurag, Gupta, Birendra Prasad, Manandhar, Krishna Das, Mishra, Shravan Kumar, Saiju, Hari Krishna, Shrestha, Rajendra Maan, Mishra, Nawneet, Sharma, Shishir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510891/
https://www.ncbi.nlm.nih.gov/pubmed/26202481
http://dx.doi.org/10.1186/s12865-015-0109-9

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