Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p

The essential vitamin biotin is a covalent and tenaciously attached prosthetic group in several carboxylases that play important roles in the regulation of energy metabolism. Here we describe increased acetyl-CoA levels and mitochondrial hyperacetylation as downstream metabolic effects of biotin def...

Descripción completa

Detalles Bibliográficos
Autores principales: Madsen, Christian T., Sylvestersen, Kathrine B., Young, Clifford, Larsen, Sara C., Poulsen, Jon W., Andersen, Marianne A., Palmqvist, Eva A., Hey-Mogensen, Martin, Jensen, Per B., Treebak, Jonas T., Lisby, Michael, Nielsen, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510963/
https://www.ncbi.nlm.nih.gov/pubmed/26158509
http://dx.doi.org/10.1038/ncomms8726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510963/
https://www.ncbi.nlm.nih.gov/pubmed/26158509
http://dx.doi.org/10.1038/ncomms8726

Ejemplares similares