Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson’s disease

BACKGROUND: The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) influences nigral dopaminergic neurons via autocrine and paracrine mechanisms. The reduction of BDNF expression in Parkinson’s disease substantia nigra (SN) might contribute to the death of dopaminergic neurons because inhibiting...

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Detalles Bibliográficos
Autores principales: Hernandez-Chan, Nancy G., Bannon, Michael J., Orozco-Barrios, Carlos E., Escobedo, Lourdes, Zamudio, Sergio, De la Cruz, Fidel, Gongora-Alfaro, Jose L., Armendáriz-Borunda, Juan, Reyes-Corona, David, Espadas-Alvarez, Armando J., Flores-Martínez, Yazmin M., Ayala-Davila, Jose, Hernandez-Gutierrez, Maria E., Pavón, Lenin, García-Villegas, Refugio, Nadella, Rasajna, Martinez-Fong, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511027/
https://www.ncbi.nlm.nih.gov/pubmed/26198255
http://dx.doi.org/10.1186/s12929-015-0166-7

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