DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

BACKGROUND: Lynch syndrome (LS) is associated with germline mutations in DNA mismatch repair (MMR) genes. The first “hit” to inactivate one allele of the predisposing MMR gene is present in every cell, contributing to accelerated tumorigenesis. Less information is available of the nature, timing, an...

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Detalles Bibliográficos
Autores principales: Valo, Satu, Kaur, Sippy, Ristimäki, Ari, Renkonen-Sinisalo, Laura, Järvinen, Heikki, Mecklin, Jukka-Pekka, Nyström, Minna, Peltomäki, Päivi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511034/
https://www.ncbi.nlm.nih.gov/pubmed/26203307
http://dx.doi.org/10.1186/s13148-015-0102-4

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