Cargando…
Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex
BACKGROUND: Sub-optimal functioning of the dorsal prefrontal cortex (PFC) is associated with executive dysfunction, such as set-shifting deficits, in neurological and psychiatric disorders. We tested this hypothesis by investigating the effect of low-frequency ‘inhibiting’ off-line repetitive transc...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511070/ https://www.ncbi.nlm.nih.gov/pubmed/26199083 http://dx.doi.org/10.1186/s12868-015-0181-3 |
_version_ | 1782382283322294272 |
---|---|
author | Gerrits, Niels J H M van den Heuvel, Odile A van der Werf, Ysbrand D |
author_facet | Gerrits, Niels J H M van den Heuvel, Odile A van der Werf, Ysbrand D |
author_sort | Gerrits, Niels J H M |
collection | PubMed |
description | BACKGROUND: Sub-optimal functioning of the dorsal prefrontal cortex (PFC) is associated with executive dysfunction, such as set-shifting deficits, in neurological and psychiatric disorders. We tested this hypothesis by investigating the effect of low-frequency ‘inhibiting’ off-line repetitive transcranial magnetic stimulation (rTMS) on the left dorsal prefrontal cortex on behavioural performance, neural activity, and network connectivity during the performance of a set-shifting paradigm in healthy elderly (mean age 50+). RESULTS: Behaviorally, we found a group-by-session interaction for errors on set-shift trials, although post hoc tests did not yield significant findings. In addition, the verum group, when compared with the sham group, displayed reduced task-related activity in the left temporal gyrus, and reduced task-related connectivity of the left PFC with the left postcentral gyrus and posterior insula. CONCLUSION: These results show that low-frequency off-line rTMS on the left dorsal PFC resulted in reduced task-related activity and network connectivity, which was accompanied by a subtle behavioural effect, thereby further corroborating the importance of an optimally functioning PFC in set-shifting. |
format | Online Article Text |
id | pubmed-4511070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45110702015-07-23 Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex Gerrits, Niels J H M van den Heuvel, Odile A van der Werf, Ysbrand D BMC Neurosci Research Article BACKGROUND: Sub-optimal functioning of the dorsal prefrontal cortex (PFC) is associated with executive dysfunction, such as set-shifting deficits, in neurological and psychiatric disorders. We tested this hypothesis by investigating the effect of low-frequency ‘inhibiting’ off-line repetitive transcranial magnetic stimulation (rTMS) on the left dorsal prefrontal cortex on behavioural performance, neural activity, and network connectivity during the performance of a set-shifting paradigm in healthy elderly (mean age 50+). RESULTS: Behaviorally, we found a group-by-session interaction for errors on set-shift trials, although post hoc tests did not yield significant findings. In addition, the verum group, when compared with the sham group, displayed reduced task-related activity in the left temporal gyrus, and reduced task-related connectivity of the left PFC with the left postcentral gyrus and posterior insula. CONCLUSION: These results show that low-frequency off-line rTMS on the left dorsal PFC resulted in reduced task-related activity and network connectivity, which was accompanied by a subtle behavioural effect, thereby further corroborating the importance of an optimally functioning PFC in set-shifting. BioMed Central 2015-07-22 /pmc/articles/PMC4511070/ /pubmed/26199083 http://dx.doi.org/10.1186/s12868-015-0181-3 Text en © Gerrits et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Gerrits, Niels J H M van den Heuvel, Odile A van der Werf, Ysbrand D Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex |
title | Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex |
title_full | Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex |
title_fullStr | Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex |
title_full_unstemmed | Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex |
title_short | Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex |
title_sort | decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511070/ https://www.ncbi.nlm.nih.gov/pubmed/26199083 http://dx.doi.org/10.1186/s12868-015-0181-3 |
work_keys_str_mv | AT gerritsnielsjhm decreasedneuralactivityandneuralconnectivitywhileperformingasetshiftingtaskafterinhibitingrepetitivetranscranialmagneticstimulationontheleftdorsalprefrontalcortex AT vandenheuvelodilea decreasedneuralactivityandneuralconnectivitywhileperformingasetshiftingtaskafterinhibitingrepetitivetranscranialmagneticstimulationontheleftdorsalprefrontalcortex AT vanderwerfysbrandd decreasedneuralactivityandneuralconnectivitywhileperformingasetshiftingtaskafterinhibitingrepetitivetranscranialmagneticstimulationontheleftdorsalprefrontalcortex |