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Left hippocampus–amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals

INTRODUCTION: Deep brain gray matter (GM) structures are involved in several neurodegenerative disorders and are affected by aging. In this study, we investigated the potential relationship between levels of brain-derived neurotrophic factor (BDNF), a putative biomarker of age- and clinically releva...

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Autores principales: Manna, Antonietta, Piras, Fabrizio, Caltagirone, Carlo, Bossù, Paola, Sensi, Stefano L, Spalletta, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511284/
https://www.ncbi.nlm.nih.gov/pubmed/26221568
http://dx.doi.org/10.1002/brb3.334
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author Manna, Antonietta
Piras, Fabrizio
Caltagirone, Carlo
Bossù, Paola
Sensi, Stefano L
Spalletta, Gianfranco
author_facet Manna, Antonietta
Piras, Fabrizio
Caltagirone, Carlo
Bossù, Paola
Sensi, Stefano L
Spalletta, Gianfranco
author_sort Manna, Antonietta
collection PubMed
description INTRODUCTION: Deep brain gray matter (GM) structures are involved in several neurodegenerative disorders and are affected by aging. In this study, we investigated the potential relationship between levels of brain-derived neurotrophic factor (BDNF), a putative biomarker of age- and clinically relevant brain dysfunctions, and the presence of structural modifications that were evaluated by magnetic resonance imaging in six deep GM structures. METHODS: Volume changes and diffusion tensor imaging (DTI) scalars were studied in the thalamus, putamen, hippocampus, caudate nucleus, amygdala and pallidum of a cohort of 120 healthy subjects. The cohort included young (18–39 years old), adult (40–59 years old) and elderly (60–76 years old) subjects. RESULTS: No correlations were seen in the young and adult cohorts. In the elderly group, we observed reduced BDNF levels that correlated with increased DTI-based mean diffusivity occurring in the left hippocampus along with decreased normalized volume in the left amygdala. CONCLUSIONS: These findings suggest that, in elderly subjects, BDNF may exert regional and lateralized effects that allow the integrity of two strategic deep GM areas such as the hippocampus and the amygdala.
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spelling pubmed-45112842015-07-28 Left hippocampus–amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals Manna, Antonietta Piras, Fabrizio Caltagirone, Carlo Bossù, Paola Sensi, Stefano L Spalletta, Gianfranco Brain Behav Original Research INTRODUCTION: Deep brain gray matter (GM) structures are involved in several neurodegenerative disorders and are affected by aging. In this study, we investigated the potential relationship between levels of brain-derived neurotrophic factor (BDNF), a putative biomarker of age- and clinically relevant brain dysfunctions, and the presence of structural modifications that were evaluated by magnetic resonance imaging in six deep GM structures. METHODS: Volume changes and diffusion tensor imaging (DTI) scalars were studied in the thalamus, putamen, hippocampus, caudate nucleus, amygdala and pallidum of a cohort of 120 healthy subjects. The cohort included young (18–39 years old), adult (40–59 years old) and elderly (60–76 years old) subjects. RESULTS: No correlations were seen in the young and adult cohorts. In the elderly group, we observed reduced BDNF levels that correlated with increased DTI-based mean diffusivity occurring in the left hippocampus along with decreased normalized volume in the left amygdala. CONCLUSIONS: These findings suggest that, in elderly subjects, BDNF may exert regional and lateralized effects that allow the integrity of two strategic deep GM areas such as the hippocampus and the amygdala. John Wiley & Sons, Ltd 2015-07 2015-05-26 /pmc/articles/PMC4511284/ /pubmed/26221568 http://dx.doi.org/10.1002/brb3.334 Text en © 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Manna, Antonietta
Piras, Fabrizio
Caltagirone, Carlo
Bossù, Paola
Sensi, Stefano L
Spalletta, Gianfranco
Left hippocampus–amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals
title Left hippocampus–amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals
title_full Left hippocampus–amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals
title_fullStr Left hippocampus–amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals
title_full_unstemmed Left hippocampus–amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals
title_short Left hippocampus–amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals
title_sort left hippocampus–amygdala complex macro- and microstructural variation is associated with bdnf plasma levels in healthy elderly individuals
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511284/
https://www.ncbi.nlm.nih.gov/pubmed/26221568
http://dx.doi.org/10.1002/brb3.334
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