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Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy
The present brief review discusses recent progress with corneal confocal microscopy for the evaluation of diabetic sensorimotor polyneuropathy. Corneal confocal microscopy is a new, non-invasive and reproducible diagnostic modality, and it can also be easily applied for patient follow up. It enables...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511296/ https://www.ncbi.nlm.nih.gov/pubmed/26221515 http://dx.doi.org/10.1111/jdi.12335 |
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author | Papanas, Nikolaos Ziegler, Dan |
author_facet | Papanas, Nikolaos Ziegler, Dan |
author_sort | Papanas, Nikolaos |
collection | PubMed |
description | The present brief review discusses recent progress with corneal confocal microscopy for the evaluation of diabetic sensorimotor polyneuropathy. Corneal confocal microscopy is a new, non-invasive and reproducible diagnostic modality, and it can also be easily applied for patient follow up. It enables new perspectives of studying the natural history of diabetic sensorimotor polyneuropathy, severity of nerve fiber pathology and documenting early nerve fiber regeneration after therapeutic intervention. It shows moderate to high sensitivity and specificity for the timely diagnosis of diabetic sensorimotor polyneuropathy. Currently, corneal confocal microscopy is mainly used in specialized centers, but deserves more widespread application for the assessment of diabetic sensorimotor polyneuropathy. Finally, further progress is required in terms of technical improvements for automated nerve fiber quantification and for analysis of larger images. |
format | Online Article Text |
id | pubmed-4511296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45112962015-07-28 Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy Papanas, Nikolaos Ziegler, Dan J Diabetes Investig Review Articles The present brief review discusses recent progress with corneal confocal microscopy for the evaluation of diabetic sensorimotor polyneuropathy. Corneal confocal microscopy is a new, non-invasive and reproducible diagnostic modality, and it can also be easily applied for patient follow up. It enables new perspectives of studying the natural history of diabetic sensorimotor polyneuropathy, severity of nerve fiber pathology and documenting early nerve fiber regeneration after therapeutic intervention. It shows moderate to high sensitivity and specificity for the timely diagnosis of diabetic sensorimotor polyneuropathy. Currently, corneal confocal microscopy is mainly used in specialized centers, but deserves more widespread application for the assessment of diabetic sensorimotor polyneuropathy. Finally, further progress is required in terms of technical improvements for automated nerve fiber quantification and for analysis of larger images. John Wiley & Sons, Ltd 2015-07 2015-03-04 /pmc/articles/PMC4511296/ /pubmed/26221515 http://dx.doi.org/10.1111/jdi.12335 Text en © 2015 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Papanas, Nikolaos Ziegler, Dan Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy |
title | Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy |
title_full | Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy |
title_fullStr | Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy |
title_full_unstemmed | Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy |
title_short | Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy |
title_sort | corneal confocal microscopy: recent progress in the evaluation of diabetic neuropathy |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511296/ https://www.ncbi.nlm.nih.gov/pubmed/26221515 http://dx.doi.org/10.1111/jdi.12335 |
work_keys_str_mv | AT papanasnikolaos cornealconfocalmicroscopyrecentprogressintheevaluationofdiabeticneuropathy AT zieglerdan cornealconfocalmicroscopyrecentprogressintheevaluationofdiabeticneuropathy |