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Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease1,2,3
Hypoxia-like tissue alterations, characterized by the upregulation of hypoxia-inducible factor-1α (HIF-1α), have been described in the normal appearing white matter and pre-demyelinating lesions of multiple sclerosis (MS) patients. As HIF-1α regulates the transcription of a wide set of genes involve...
Autores principales: | Le Moan, Natacha, Baeten, Kim M., Rafalski, Victoria A., Kyu Ryu, Jae, Rios Coronado, Pamela E., Bedard, Catherine, Syme, Catriona, Davalos, Dimitrios, Akassoglou, Katerina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511492/ https://www.ncbi.nlm.nih.gov/pubmed/26213713 http://dx.doi.org/10.1523/ENEURO.0050-14.2015 |
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