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Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life

BACKGROUND: To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics of infants at high familial risk for ASD (HR), and infants at low risk (LR). METHODS: Participants included 210 HR and 98 LR infants across 4 sites with co...

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Autores principales: Estes, Annette, Zwaigenbaum, Lonnie, Gu, Hongbin, St. John, Tanya, Paterson, Sarah, Elison, Jed T., Hazlett, Heather, Botteron, Kelly, Dager, Stephen R., Schultz, Robert T., Kostopoulos, Penelope, Evans, Alan, Dawson, Geraldine, Eliason, Jordana, Alvarez, Shanna, Piven, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511527/
https://www.ncbi.nlm.nih.gov/pubmed/26203305
http://dx.doi.org/10.1186/s11689-015-9117-6
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author Estes, Annette
Zwaigenbaum, Lonnie
Gu, Hongbin
St. John, Tanya
Paterson, Sarah
Elison, Jed T.
Hazlett, Heather
Botteron, Kelly
Dager, Stephen R.
Schultz, Robert T.
Kostopoulos, Penelope
Evans, Alan
Dawson, Geraldine
Eliason, Jordana
Alvarez, Shanna
Piven, Joseph
author_facet Estes, Annette
Zwaigenbaum, Lonnie
Gu, Hongbin
St. John, Tanya
Paterson, Sarah
Elison, Jed T.
Hazlett, Heather
Botteron, Kelly
Dager, Stephen R.
Schultz, Robert T.
Kostopoulos, Penelope
Evans, Alan
Dawson, Geraldine
Eliason, Jordana
Alvarez, Shanna
Piven, Joseph
author_sort Estes, Annette
collection PubMed
description BACKGROUND: To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics of infants at high familial risk for ASD (HR), and infants at low risk (LR). METHODS: Participants included 210 HR and 98 LR infants across 4 sites with comparable behavioral data at age 6, 12, and 24 months assessed in the domains of cognitive development (Mullen Scales of Early Learning), adaptive skills (Vineland Adaptive Behavioral Scales), and early behavioral features of ASD (Autism Observation Scale for Infants). Participants evaluated according to the DSM-IV-TR criteria at 24 months and categorized as ASD-positive or ASD-negative were further stratified by empirically derived cutoff scores using the Autism Diagnostic Observation Schedule yielding four groups: HR-ASD-High, HR-ASD-Moderate (HR-ASD-Mod), HR-ASD-Negative (HR-Neg), and LR-ASD-Negative (LR-Neg). RESULTS: The four groups demonstrated different developmental trajectories that became increasingly distinct from 6 to 24 months across all domains. At 6 months, the HR-ASD-High group demonstrated less advanced Gross Motor and Visual Reception skills compared with the LR-Neg group. By 12 months, the HR-ASD-High group demonstrated increased behavioral features of ASD and decreased cognitive and adaptive functioning compared to the HR-Neg and LR-Neg groups. By 24 months, both the HR-ASD-High and HR-ASD-Moderate groups demonstrated differences from the LR- and HR-Neg groups in all domains. CONCLUSIONS: These findings reveal atypical sensorimotor development at 6 months of age which is associated with ASD at 24 months in the most severely affected group of infants. Sensorimotor differences precede the unfolding of cognitive and adaptive deficits and behavioral features of autism across the 6- to 24-month interval. The less severely affected group demonstrates later symptom onset, in the second year of life, with initial differences in the social-communication domain. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11689-015-9117-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-45115272015-07-23 Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life Estes, Annette Zwaigenbaum, Lonnie Gu, Hongbin St. John, Tanya Paterson, Sarah Elison, Jed T. Hazlett, Heather Botteron, Kelly Dager, Stephen R. Schultz, Robert T. Kostopoulos, Penelope Evans, Alan Dawson, Geraldine Eliason, Jordana Alvarez, Shanna Piven, Joseph J Neurodev Disord Research BACKGROUND: To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics of infants at high familial risk for ASD (HR), and infants at low risk (LR). METHODS: Participants included 210 HR and 98 LR infants across 4 sites with comparable behavioral data at age 6, 12, and 24 months assessed in the domains of cognitive development (Mullen Scales of Early Learning), adaptive skills (Vineland Adaptive Behavioral Scales), and early behavioral features of ASD (Autism Observation Scale for Infants). Participants evaluated according to the DSM-IV-TR criteria at 24 months and categorized as ASD-positive or ASD-negative were further stratified by empirically derived cutoff scores using the Autism Diagnostic Observation Schedule yielding four groups: HR-ASD-High, HR-ASD-Moderate (HR-ASD-Mod), HR-ASD-Negative (HR-Neg), and LR-ASD-Negative (LR-Neg). RESULTS: The four groups demonstrated different developmental trajectories that became increasingly distinct from 6 to 24 months across all domains. At 6 months, the HR-ASD-High group demonstrated less advanced Gross Motor and Visual Reception skills compared with the LR-Neg group. By 12 months, the HR-ASD-High group demonstrated increased behavioral features of ASD and decreased cognitive and adaptive functioning compared to the HR-Neg and LR-Neg groups. By 24 months, both the HR-ASD-High and HR-ASD-Moderate groups demonstrated differences from the LR- and HR-Neg groups in all domains. CONCLUSIONS: These findings reveal atypical sensorimotor development at 6 months of age which is associated with ASD at 24 months in the most severely affected group of infants. Sensorimotor differences precede the unfolding of cognitive and adaptive deficits and behavioral features of autism across the 6- to 24-month interval. The less severely affected group demonstrates later symptom onset, in the second year of life, with initial differences in the social-communication domain. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11689-015-9117-6) contains supplementary material, which is available to authorized users. BioMed Central 2015-07-16 2015 /pmc/articles/PMC4511527/ /pubmed/26203305 http://dx.doi.org/10.1186/s11689-015-9117-6 Text en © Estes et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Estes, Annette
Zwaigenbaum, Lonnie
Gu, Hongbin
St. John, Tanya
Paterson, Sarah
Elison, Jed T.
Hazlett, Heather
Botteron, Kelly
Dager, Stephen R.
Schultz, Robert T.
Kostopoulos, Penelope
Evans, Alan
Dawson, Geraldine
Eliason, Jordana
Alvarez, Shanna
Piven, Joseph
Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life
title Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life
title_full Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life
title_fullStr Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life
title_full_unstemmed Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life
title_short Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life
title_sort behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511527/
https://www.ncbi.nlm.nih.gov/pubmed/26203305
http://dx.doi.org/10.1186/s11689-015-9117-6
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