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Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study

BACKGROUND: Metabolic syndrome (MetS) is an important risk factor for cerebral ischemic stroke, yet previous studies on the relationship between MetS or its components and acute cerebral infarction have been inconsistent. This study aims to evaluate the effects of MetS and its components on the shor...

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Autores principales: Liu, Liu, Zhan, Lixuan, Wang, Yisheng, Bai, Chengping, Guo, Jianjun, Lin, Qingyuan, Liang, Donghai, Xu, En
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511539/
https://www.ncbi.nlm.nih.gov/pubmed/26199022
http://dx.doi.org/10.1186/s12944-015-0080-8
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author Liu, Liu
Zhan, Lixuan
Wang, Yisheng
Bai, Chengping
Guo, Jianjun
Lin, Qingyuan
Liang, Donghai
Xu, En
author_facet Liu, Liu
Zhan, Lixuan
Wang, Yisheng
Bai, Chengping
Guo, Jianjun
Lin, Qingyuan
Liang, Donghai
Xu, En
author_sort Liu, Liu
collection PubMed
description BACKGROUND: Metabolic syndrome (MetS) is an important risk factor for cerebral ischemic stroke, yet previous studies on the relationship between MetS or its components and acute cerebral infarction have been inconsistent. This study aims to evaluate the effects of MetS and its components on the short-term prognosis of patients with acute ischemic stroke. METHODS: Subjects with ischemic stroke of <7-day duration (530 cases) were enrolled. MetS was defined based on the modified criteria of the International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute. Demographic data, vascular risk factors, National Institutes of Health Stroke Scale score, the results of physical, laboratory and imaging examinations and clinical outcomes at 30 and 90 days were recorded. Using univariate analysis, we compared different baseline characteristics between patients with MetS and those without MetS. Further, we assessed MetS and its 5 components on the contribution to short-term prognosis of ischemic stroke with multiple logistic regression models after adjusting for age and sex. RESULTS: The prevalence of MetS among the patients with acute ischemic stroke in the study is 58.3 %, with more in females (70.3 %) than in males (49.7 %, p < 0.001). As expected, among the MetS components, elevated waist circumference, elevated triglyceride, high fasting blood glucose and low high density lipoprotein cholesterol (HDL-C) were significantly more prevalent in patients with MetS than those without MetS (all p < 0.001). There was no correlation between MetS itself and the short-term prognosis of acute ischemic stroke. Only hyperglycemia in the serum was shown to have impact on poor functional outcomes in 30 and 90 days after the onset of stroke. CONCLUSIONS: The occurrence of MetS among patients with acute ischemic stroke in our study is 58.3 %. MetS itself may not be predictive for the short-term prognosis of patients, while hyperglycemia is a significant predictor for poor functional outcomes in our study.
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spelling pubmed-45115392015-07-23 Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study Liu, Liu Zhan, Lixuan Wang, Yisheng Bai, Chengping Guo, Jianjun Lin, Qingyuan Liang, Donghai Xu, En Lipids Health Dis Research BACKGROUND: Metabolic syndrome (MetS) is an important risk factor for cerebral ischemic stroke, yet previous studies on the relationship between MetS or its components and acute cerebral infarction have been inconsistent. This study aims to evaluate the effects of MetS and its components on the short-term prognosis of patients with acute ischemic stroke. METHODS: Subjects with ischemic stroke of <7-day duration (530 cases) were enrolled. MetS was defined based on the modified criteria of the International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute. Demographic data, vascular risk factors, National Institutes of Health Stroke Scale score, the results of physical, laboratory and imaging examinations and clinical outcomes at 30 and 90 days were recorded. Using univariate analysis, we compared different baseline characteristics between patients with MetS and those without MetS. Further, we assessed MetS and its 5 components on the contribution to short-term prognosis of ischemic stroke with multiple logistic regression models after adjusting for age and sex. RESULTS: The prevalence of MetS among the patients with acute ischemic stroke in the study is 58.3 %, with more in females (70.3 %) than in males (49.7 %, p < 0.001). As expected, among the MetS components, elevated waist circumference, elevated triglyceride, high fasting blood glucose and low high density lipoprotein cholesterol (HDL-C) were significantly more prevalent in patients with MetS than those without MetS (all p < 0.001). There was no correlation between MetS itself and the short-term prognosis of acute ischemic stroke. Only hyperglycemia in the serum was shown to have impact on poor functional outcomes in 30 and 90 days after the onset of stroke. CONCLUSIONS: The occurrence of MetS among patients with acute ischemic stroke in our study is 58.3 %. MetS itself may not be predictive for the short-term prognosis of patients, while hyperglycemia is a significant predictor for poor functional outcomes in our study. BioMed Central 2015-07-22 /pmc/articles/PMC4511539/ /pubmed/26199022 http://dx.doi.org/10.1186/s12944-015-0080-8 Text en © Liu et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Liu, Liu
Zhan, Lixuan
Wang, Yisheng
Bai, Chengping
Guo, Jianjun
Lin, Qingyuan
Liang, Donghai
Xu, En
Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
title Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
title_full Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
title_fullStr Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
title_full_unstemmed Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
title_short Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
title_sort metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511539/
https://www.ncbi.nlm.nih.gov/pubmed/26199022
http://dx.doi.org/10.1186/s12944-015-0080-8
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