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Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study

INTRODUCTION: Little is known about medication use among women with eating disorders in relation to pregnancy. AIMS: To explore patterns of and associations between use of psychotropic, gastrointestinal and analgesic medications and eating disorders in the period before, during and after pregnancy....

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Autores principales: Lupattelli, Angela, Spigset, Olav, Torgersen, Leila, Zerwas, Stephanie, Hatle, Marianne, Reichborn-Kjennerud, Ted, Bulik, Cynthia M., Nordeng, Hedvig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511584/
https://www.ncbi.nlm.nih.gov/pubmed/26200658
http://dx.doi.org/10.1371/journal.pone.0133045
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author Lupattelli, Angela
Spigset, Olav
Torgersen, Leila
Zerwas, Stephanie
Hatle, Marianne
Reichborn-Kjennerud, Ted
Bulik, Cynthia M.
Nordeng, Hedvig
author_facet Lupattelli, Angela
Spigset, Olav
Torgersen, Leila
Zerwas, Stephanie
Hatle, Marianne
Reichborn-Kjennerud, Ted
Bulik, Cynthia M.
Nordeng, Hedvig
author_sort Lupattelli, Angela
collection PubMed
description INTRODUCTION: Little is known about medication use among women with eating disorders in relation to pregnancy. AIMS: To explore patterns of and associations between use of psychotropic, gastrointestinal and analgesic medications and eating disorders in the period before, during and after pregnancy. METHOD: This study is based on the Norwegian Mother and Child Cohort Study (MoBa). A total of 62,019 women, enrolled at approximately 17 weeks' gestation, had valid data from the Norwegian Medical Birth Registry and completed three MoBa questionnaires. The questionnaires provided diagnostic information on broadly defined anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED) and recurrent self-induced purging in the absence of binge eating (EDNOS-P), along with self-reported use of medication six months before, during, and 0–6 months after pregnancy. RESULTS: The prevalence of eating disorder subtypes before and/or during pregnancy was: 0.09% AN (n = 54), 0.94% BN (n = 585), 0.10% EDNOS-P (n = 61) and 5.00% BED (n = 3104). The highest over-time prevalence of psychotropic use was within the AN (3.7–22.2%) and EDNOS-P (3.3–9.8%) groups. Compared to controls, BN was directly associated with incident use of psychotropics in pregnancy (adjusted RR: 2.25, 99% CI: 1.17–4.32). Having AN (adjusted RR: 5.11, 99% CI: 1.53–17.01) or EDNOS-P (adjusted RR: 6.77, 99% CI: 1.41–32.53) was directly associated with use of anxiolytics/sedatives postpartum. The estimates of use of analgesics (BED) and laxatives (all eating disorders subtypes) were high at all time periods investigated. CONCLUSIONS: Use of psychotropic, gastrointestinal, and analgesic medications is extensive among women with eating disorders in the period around pregnancy. Female patients with eating disorders should receive evidence-based counseling about the risk of medication exposure versus the risk of untreated psychiatric illness during pregnancy and postpartum.
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spelling pubmed-45115842015-07-24 Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study Lupattelli, Angela Spigset, Olav Torgersen, Leila Zerwas, Stephanie Hatle, Marianne Reichborn-Kjennerud, Ted Bulik, Cynthia M. Nordeng, Hedvig PLoS One Research Article INTRODUCTION: Little is known about medication use among women with eating disorders in relation to pregnancy. AIMS: To explore patterns of and associations between use of psychotropic, gastrointestinal and analgesic medications and eating disorders in the period before, during and after pregnancy. METHOD: This study is based on the Norwegian Mother and Child Cohort Study (MoBa). A total of 62,019 women, enrolled at approximately 17 weeks' gestation, had valid data from the Norwegian Medical Birth Registry and completed three MoBa questionnaires. The questionnaires provided diagnostic information on broadly defined anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED) and recurrent self-induced purging in the absence of binge eating (EDNOS-P), along with self-reported use of medication six months before, during, and 0–6 months after pregnancy. RESULTS: The prevalence of eating disorder subtypes before and/or during pregnancy was: 0.09% AN (n = 54), 0.94% BN (n = 585), 0.10% EDNOS-P (n = 61) and 5.00% BED (n = 3104). The highest over-time prevalence of psychotropic use was within the AN (3.7–22.2%) and EDNOS-P (3.3–9.8%) groups. Compared to controls, BN was directly associated with incident use of psychotropics in pregnancy (adjusted RR: 2.25, 99% CI: 1.17–4.32). Having AN (adjusted RR: 5.11, 99% CI: 1.53–17.01) or EDNOS-P (adjusted RR: 6.77, 99% CI: 1.41–32.53) was directly associated with use of anxiolytics/sedatives postpartum. The estimates of use of analgesics (BED) and laxatives (all eating disorders subtypes) were high at all time periods investigated. CONCLUSIONS: Use of psychotropic, gastrointestinal, and analgesic medications is extensive among women with eating disorders in the period around pregnancy. Female patients with eating disorders should receive evidence-based counseling about the risk of medication exposure versus the risk of untreated psychiatric illness during pregnancy and postpartum. Public Library of Science 2015-07-22 /pmc/articles/PMC4511584/ /pubmed/26200658 http://dx.doi.org/10.1371/journal.pone.0133045 Text en © 2015 Lupattelli et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lupattelli, Angela
Spigset, Olav
Torgersen, Leila
Zerwas, Stephanie
Hatle, Marianne
Reichborn-Kjennerud, Ted
Bulik, Cynthia M.
Nordeng, Hedvig
Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study
title Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study
title_full Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study
title_fullStr Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study
title_full_unstemmed Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study
title_short Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study
title_sort medication use before, during, and after pregnancy among women with eating disorders: a study from the norwegian mother and child cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511584/
https://www.ncbi.nlm.nih.gov/pubmed/26200658
http://dx.doi.org/10.1371/journal.pone.0133045
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