HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)

INTRODUCTION: HDAC isoform-specific inhibitors may improve the therapeutic window while limiting toxicities. Developing inhibitors against class I isoforms poses difficulties as they share high homology among their catalytic sites; however, HDAC8 is structurally unique compared to other class I isof...

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Detalles Bibliográficos
Autores principales: Lopez, Gonzalo, Bill, Kate Lynn J., Bid, Hemant Kumar, Braggio, Danielle, Constantino, Dylan, Prudner, Bethany, Zewdu, Abeba, Batte, Kara, Lev, Dina, Pollock, Raphael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511720/
https://www.ncbi.nlm.nih.gov/pubmed/26200462
http://dx.doi.org/10.1371/journal.pone.0133302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511720/
https://www.ncbi.nlm.nih.gov/pubmed/26200462
http://dx.doi.org/10.1371/journal.pone.0133302

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