Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities

Many therapeutic antibodies have been developed, and IgG antibodies have been extensively generated in various cell expression systems. IgG antibodies contain N-glycans at the constant region of the heavy chain (Fc domain), and their N-glycosylation patterns differ during various processes or among...

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Detalles Bibliográficos
Autores principales: Kurogochi, Masaki, Mori, Masako, Osumi, Kenji, Tojino, Mami, Sugawara, Shu-ichi, Takashima, Shou, Hirose, Yuriko, Tsukimura, Wataru, Mizuno, Mamoru, Amano, Junko, Matsuda, Akio, Tomita, Masahiro, Takayanagi, Atsushi, Shoda, Shin-Ichiro, Shirai, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511734/
https://www.ncbi.nlm.nih.gov/pubmed/26200113
http://dx.doi.org/10.1371/journal.pone.0132848

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