Two Distinct Hepatitis C Virus Genotype 1a Clades Have Different Geographical Distribution and Association With Natural Resistance to NS3 Protease Inhibitors

Background. Hepatitis C virus (HCV) genotype 1 is the most prevalent worldwide. Subtype 1a, compared with 1b, shows lower response rates and higher propensity to select for drug resistance to NS3 and selected NS5A and nonnucleoside NS5B inhibitors. Two distinct clades of subtype 1a have been describ...

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Detalles Bibliográficos
Autores principales: De Luca, Andrea, Di Giambenedetto, Simona, Lo Presti, Alessandra, Sierra, Saleta, Prosperi, Mattia, Cella, Eleonora, Giovanetti, Marta, Torti, Carlo, Caudai, Cinzia, Vicenti, Ilaria, Saladini, Francesco, Almi, Paolo, Grima, Pierfrancesco, Blanc, Pierluigi, Fabbiani, Massimiliano, Rossetti, Barbara, Gagliardini, Roberta, Kaiser, Rolf, Ciccozzi, Massimo, Zazzi, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Major Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511743/
https://www.ncbi.nlm.nih.gov/pubmed/26213689
http://dx.doi.org/10.1093/ofid/ofv043

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