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Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism

Brain arginine vasopressin (AVP) critically regulates normative social behavior in mammals, and experimental disruption of the AVP signaling pathway produces social impairments in rodent models. We therefore hypothesized that AVP signaling deficits may contribute to social impairments in children wi...

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Autores principales: Carson, Dean S., Garner, Joseph P., Hyde, Shellie A., Libove, Robin A., Berquist, Sean W., Hornbeak, Kirsten B., Jackson, Lisa P., Sumiyoshi, Raena D., Howerton, Christopher L., Hannah, Sadie L., Partap, Sonia, Phillips, Jennifer M., Hardan, Antonio Y., Parker, Karen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511760/
https://www.ncbi.nlm.nih.gov/pubmed/26200852
http://dx.doi.org/10.1371/journal.pone.0132224
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author Carson, Dean S.
Garner, Joseph P.
Hyde, Shellie A.
Libove, Robin A.
Berquist, Sean W.
Hornbeak, Kirsten B.
Jackson, Lisa P.
Sumiyoshi, Raena D.
Howerton, Christopher L.
Hannah, Sadie L.
Partap, Sonia
Phillips, Jennifer M.
Hardan, Antonio Y.
Parker, Karen J.
author_facet Carson, Dean S.
Garner, Joseph P.
Hyde, Shellie A.
Libove, Robin A.
Berquist, Sean W.
Hornbeak, Kirsten B.
Jackson, Lisa P.
Sumiyoshi, Raena D.
Howerton, Christopher L.
Hannah, Sadie L.
Partap, Sonia
Phillips, Jennifer M.
Hardan, Antonio Y.
Parker, Karen J.
author_sort Carson, Dean S.
collection PubMed
description Brain arginine vasopressin (AVP) critically regulates normative social behavior in mammals, and experimental disruption of the AVP signaling pathway produces social impairments in rodent models. We therefore hypothesized that AVP signaling deficits may contribute to social impairments in children with autism spectrum disorder (ASD). Since blood measures (which are far easier to obtain than brain measures) of AVP are most meaningful if they are related to brain AVP activity, Study 1 tested the relationship between AVP concentrations in concomitantly collected blood and CSF samples from children and adults (N = 28) undergoing clinical procedures. Study 2 tested whether blood AVP concentrations: 1) differed between children with ASD (N = 57), their ASD discordant siblings (N = 47), and neurotypical controls (N = 55); and 2) predicted social functioning (using the NEPSY-II Theory of Mind and Affect Recognition tasks and the Social Responsiveness Scale) in this large, well-characterized child cohort. Blood AVP concentrations significantly and positively predicted CSF AVP concentrations (F (1,26) = 7.17, r = 0.46, p = 0.0127) in Study 1. In Study 2, blood AVP concentrations did not differ between groups or by sex, but significantly and positively predicted Theory of Mind performance, specifically in children with ASD, but not in non-ASD children (F (1,144) = 5.83, p = 0.017). Blood AVP concentrations can be used: 1) as a surrogate for brain AVP activity in humans; and 2) as a robust biomarker of theory of mind ability in children with ASD. These findings also suggest that AVP biology may be a promising therapeutic target by which to improve social cognition in individuals with ASD.
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spelling pubmed-45117602015-07-24 Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism Carson, Dean S. Garner, Joseph P. Hyde, Shellie A. Libove, Robin A. Berquist, Sean W. Hornbeak, Kirsten B. Jackson, Lisa P. Sumiyoshi, Raena D. Howerton, Christopher L. Hannah, Sadie L. Partap, Sonia Phillips, Jennifer M. Hardan, Antonio Y. Parker, Karen J. PLoS One Research Article Brain arginine vasopressin (AVP) critically regulates normative social behavior in mammals, and experimental disruption of the AVP signaling pathway produces social impairments in rodent models. We therefore hypothesized that AVP signaling deficits may contribute to social impairments in children with autism spectrum disorder (ASD). Since blood measures (which are far easier to obtain than brain measures) of AVP are most meaningful if they are related to brain AVP activity, Study 1 tested the relationship between AVP concentrations in concomitantly collected blood and CSF samples from children and adults (N = 28) undergoing clinical procedures. Study 2 tested whether blood AVP concentrations: 1) differed between children with ASD (N = 57), their ASD discordant siblings (N = 47), and neurotypical controls (N = 55); and 2) predicted social functioning (using the NEPSY-II Theory of Mind and Affect Recognition tasks and the Social Responsiveness Scale) in this large, well-characterized child cohort. Blood AVP concentrations significantly and positively predicted CSF AVP concentrations (F (1,26) = 7.17, r = 0.46, p = 0.0127) in Study 1. In Study 2, blood AVP concentrations did not differ between groups or by sex, but significantly and positively predicted Theory of Mind performance, specifically in children with ASD, but not in non-ASD children (F (1,144) = 5.83, p = 0.017). Blood AVP concentrations can be used: 1) as a surrogate for brain AVP activity in humans; and 2) as a robust biomarker of theory of mind ability in children with ASD. These findings also suggest that AVP biology may be a promising therapeutic target by which to improve social cognition in individuals with ASD. Public Library of Science 2015-07-22 /pmc/articles/PMC4511760/ /pubmed/26200852 http://dx.doi.org/10.1371/journal.pone.0132224 Text en © 2015 Carson et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Carson, Dean S.
Garner, Joseph P.
Hyde, Shellie A.
Libove, Robin A.
Berquist, Sean W.
Hornbeak, Kirsten B.
Jackson, Lisa P.
Sumiyoshi, Raena D.
Howerton, Christopher L.
Hannah, Sadie L.
Partap, Sonia
Phillips, Jennifer M.
Hardan, Antonio Y.
Parker, Karen J.
Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism
title Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism
title_full Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism
title_fullStr Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism
title_full_unstemmed Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism
title_short Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism
title_sort arginine vasopressin is a blood-based biomarker of social functioning in children with autism
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511760/
https://www.ncbi.nlm.nih.gov/pubmed/26200852
http://dx.doi.org/10.1371/journal.pone.0132224
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