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Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism
Brain arginine vasopressin (AVP) critically regulates normative social behavior in mammals, and experimental disruption of the AVP signaling pathway produces social impairments in rodent models. We therefore hypothesized that AVP signaling deficits may contribute to social impairments in children wi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511760/ https://www.ncbi.nlm.nih.gov/pubmed/26200852 http://dx.doi.org/10.1371/journal.pone.0132224 |
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author | Carson, Dean S. Garner, Joseph P. Hyde, Shellie A. Libove, Robin A. Berquist, Sean W. Hornbeak, Kirsten B. Jackson, Lisa P. Sumiyoshi, Raena D. Howerton, Christopher L. Hannah, Sadie L. Partap, Sonia Phillips, Jennifer M. Hardan, Antonio Y. Parker, Karen J. |
author_facet | Carson, Dean S. Garner, Joseph P. Hyde, Shellie A. Libove, Robin A. Berquist, Sean W. Hornbeak, Kirsten B. Jackson, Lisa P. Sumiyoshi, Raena D. Howerton, Christopher L. Hannah, Sadie L. Partap, Sonia Phillips, Jennifer M. Hardan, Antonio Y. Parker, Karen J. |
author_sort | Carson, Dean S. |
collection | PubMed |
description | Brain arginine vasopressin (AVP) critically regulates normative social behavior in mammals, and experimental disruption of the AVP signaling pathway produces social impairments in rodent models. We therefore hypothesized that AVP signaling deficits may contribute to social impairments in children with autism spectrum disorder (ASD). Since blood measures (which are far easier to obtain than brain measures) of AVP are most meaningful if they are related to brain AVP activity, Study 1 tested the relationship between AVP concentrations in concomitantly collected blood and CSF samples from children and adults (N = 28) undergoing clinical procedures. Study 2 tested whether blood AVP concentrations: 1) differed between children with ASD (N = 57), their ASD discordant siblings (N = 47), and neurotypical controls (N = 55); and 2) predicted social functioning (using the NEPSY-II Theory of Mind and Affect Recognition tasks and the Social Responsiveness Scale) in this large, well-characterized child cohort. Blood AVP concentrations significantly and positively predicted CSF AVP concentrations (F (1,26) = 7.17, r = 0.46, p = 0.0127) in Study 1. In Study 2, blood AVP concentrations did not differ between groups or by sex, but significantly and positively predicted Theory of Mind performance, specifically in children with ASD, but not in non-ASD children (F (1,144) = 5.83, p = 0.017). Blood AVP concentrations can be used: 1) as a surrogate for brain AVP activity in humans; and 2) as a robust biomarker of theory of mind ability in children with ASD. These findings also suggest that AVP biology may be a promising therapeutic target by which to improve social cognition in individuals with ASD. |
format | Online Article Text |
id | pubmed-4511760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45117602015-07-24 Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism Carson, Dean S. Garner, Joseph P. Hyde, Shellie A. Libove, Robin A. Berquist, Sean W. Hornbeak, Kirsten B. Jackson, Lisa P. Sumiyoshi, Raena D. Howerton, Christopher L. Hannah, Sadie L. Partap, Sonia Phillips, Jennifer M. Hardan, Antonio Y. Parker, Karen J. PLoS One Research Article Brain arginine vasopressin (AVP) critically regulates normative social behavior in mammals, and experimental disruption of the AVP signaling pathway produces social impairments in rodent models. We therefore hypothesized that AVP signaling deficits may contribute to social impairments in children with autism spectrum disorder (ASD). Since blood measures (which are far easier to obtain than brain measures) of AVP are most meaningful if they are related to brain AVP activity, Study 1 tested the relationship between AVP concentrations in concomitantly collected blood and CSF samples from children and adults (N = 28) undergoing clinical procedures. Study 2 tested whether blood AVP concentrations: 1) differed between children with ASD (N = 57), their ASD discordant siblings (N = 47), and neurotypical controls (N = 55); and 2) predicted social functioning (using the NEPSY-II Theory of Mind and Affect Recognition tasks and the Social Responsiveness Scale) in this large, well-characterized child cohort. Blood AVP concentrations significantly and positively predicted CSF AVP concentrations (F (1,26) = 7.17, r = 0.46, p = 0.0127) in Study 1. In Study 2, blood AVP concentrations did not differ between groups or by sex, but significantly and positively predicted Theory of Mind performance, specifically in children with ASD, but not in non-ASD children (F (1,144) = 5.83, p = 0.017). Blood AVP concentrations can be used: 1) as a surrogate for brain AVP activity in humans; and 2) as a robust biomarker of theory of mind ability in children with ASD. These findings also suggest that AVP biology may be a promising therapeutic target by which to improve social cognition in individuals with ASD. Public Library of Science 2015-07-22 /pmc/articles/PMC4511760/ /pubmed/26200852 http://dx.doi.org/10.1371/journal.pone.0132224 Text en © 2015 Carson et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Carson, Dean S. Garner, Joseph P. Hyde, Shellie A. Libove, Robin A. Berquist, Sean W. Hornbeak, Kirsten B. Jackson, Lisa P. Sumiyoshi, Raena D. Howerton, Christopher L. Hannah, Sadie L. Partap, Sonia Phillips, Jennifer M. Hardan, Antonio Y. Parker, Karen J. Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism |
title | Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism |
title_full | Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism |
title_fullStr | Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism |
title_full_unstemmed | Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism |
title_short | Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism |
title_sort | arginine vasopressin is a blood-based biomarker of social functioning in children with autism |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511760/ https://www.ncbi.nlm.nih.gov/pubmed/26200852 http://dx.doi.org/10.1371/journal.pone.0132224 |
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