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Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases

Genome-wide association studies (GWAS) have generated sufficient data to assess the role of selection in shaping allelic diversity of disease-associated SNPs. Negative selection against disease risk variants is expected to reduce their frequencies making them overrepresented in the group of minor (&...

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Detalles Bibliográficos
Autores principales:	Gorlov, Ivan P., Gorlova, Olga Y., Amos, Christopher I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511800/ https://www.ncbi.nlm.nih.gov/pubmed/26201053 http://dx.doi.org/10.1371/journal.pgen.1005371

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