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Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age

Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is defined as patients older than 50 years alone. However, recent studies showed young patients with sound immune status could also be affected. In this study, we investigated the clinical features and outcomes of...

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Autores principales: Lu, Ting-Xun, Liang, Jin-Hua, Miao, Yi, Fan, Lei, Wang, Li, Qu, Xiao-Yan, Cao, Lei, Gong, Qi-Xing, Wang, Zhen, Zhang, Zhi-Hong, Xu, Wei, Li, Jian-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511873/
https://www.ncbi.nlm.nih.gov/pubmed/26202875
http://dx.doi.org/10.1038/srep12168
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author Lu, Ting-Xun
Liang, Jin-Hua
Miao, Yi
Fan, Lei
Wang, Li
Qu, Xiao-Yan
Cao, Lei
Gong, Qi-Xing
Wang, Zhen
Zhang, Zhi-Hong
Xu, Wei
Li, Jian-Yong
author_facet Lu, Ting-Xun
Liang, Jin-Hua
Miao, Yi
Fan, Lei
Wang, Li
Qu, Xiao-Yan
Cao, Lei
Gong, Qi-Xing
Wang, Zhen
Zhang, Zhi-Hong
Xu, Wei
Li, Jian-Yong
author_sort Lu, Ting-Xun
collection PubMed
description Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is defined as patients older than 50 years alone. However, recent studies showed young patients with sound immune status could also be affected. In this study, we investigated the clinical features and outcomes of patients with EBV positive DLBCL in the different age groups using different EBER cut-off values. The prevalence of EBV positive DLBCL was 14.0% (35/250) and 10.4% (26/250) for EBER cut-off of 20% and 50%, respectively. With both EBER cut-off values, patients with EBV DLBCL shared many unfavorable prognostic characteristics, regardless of age. EBV positive patients, both in the elderly and young groups, showed significantly worse overall survival and progression-free survival than negative cases. Moreover, no significant differences of outcomes were identified between different age groups with EBV positive DLBCL. In conclusion, EBV positive DLBCL patients, regardless of age, shared similar poor prognostic features and showed worse outcome than negative cases. We suggest that the age criterion of EBV positive DLBCL of the elderly, and possibly the name itself, be modified in future.
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spelling pubmed-45118732015-07-28 Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age Lu, Ting-Xun Liang, Jin-Hua Miao, Yi Fan, Lei Wang, Li Qu, Xiao-Yan Cao, Lei Gong, Qi-Xing Wang, Zhen Zhang, Zhi-Hong Xu, Wei Li, Jian-Yong Sci Rep Article Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is defined as patients older than 50 years alone. However, recent studies showed young patients with sound immune status could also be affected. In this study, we investigated the clinical features and outcomes of patients with EBV positive DLBCL in the different age groups using different EBER cut-off values. The prevalence of EBV positive DLBCL was 14.0% (35/250) and 10.4% (26/250) for EBER cut-off of 20% and 50%, respectively. With both EBER cut-off values, patients with EBV DLBCL shared many unfavorable prognostic characteristics, regardless of age. EBV positive patients, both in the elderly and young groups, showed significantly worse overall survival and progression-free survival than negative cases. Moreover, no significant differences of outcomes were identified between different age groups with EBV positive DLBCL. In conclusion, EBV positive DLBCL patients, regardless of age, shared similar poor prognostic features and showed worse outcome than negative cases. We suggest that the age criterion of EBV positive DLBCL of the elderly, and possibly the name itself, be modified in future. Nature Publishing Group 2015-07-23 /pmc/articles/PMC4511873/ /pubmed/26202875 http://dx.doi.org/10.1038/srep12168 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lu, Ting-Xun
Liang, Jin-Hua
Miao, Yi
Fan, Lei
Wang, Li
Qu, Xiao-Yan
Cao, Lei
Gong, Qi-Xing
Wang, Zhen
Zhang, Zhi-Hong
Xu, Wei
Li, Jian-Yong
Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age
title Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age
title_full Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age
title_fullStr Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age
title_full_unstemmed Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age
title_short Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age
title_sort epstein-barr virus positive diffuse large b-cell lymphoma predict poor outcome, regardless of the age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511873/
https://www.ncbi.nlm.nih.gov/pubmed/26202875
http://dx.doi.org/10.1038/srep12168
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