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Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy

BACKGROUND: Aberrant activation of fibroblast growth factor receptors (FGFRs) deregulates cell proliferation and promotes cell survival, and may predispose to tumorigenesis. Therefore, selective inactivation of FGFRs is an important strategy for cancer therapy. Here as a proof-of-concept study, we d...

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Detalles Bibliográficos
Autores principales:	Ling, Ling, Tan, Si Kee, Goh, Ting Hwee, Cheung, Edwin, Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511971/ https://www.ncbi.nlm.nih.gov/pubmed/26201468 http://dx.doi.org/10.1186/s12943-015-0391-4

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