Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. While the multi-step model of pediatric leukemogenesis suggests interplay between constitutional and somatic genomes, the role of inherited genetic variability remains largely undescribed. Nonsyndromic familial ALL,...

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Detalles Bibliográficos
Autores principales: Spinella, Jean-François, Healy, Jasmine, Saillour, Virginie, Richer, Chantal, Cassart, Pauline, Ouimet, Manon, Sinnett, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512039/
https://www.ncbi.nlm.nih.gov/pubmed/26201965
http://dx.doi.org/10.1186/s12885-015-1549-6

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