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Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico

High-risk human papillomaviruses (HR-HPV) are considered necessary for the development of cervical cancer. Furthermore, there is no doubt that some types of oral squamous cell carcinoma are associated with HR-HPV. The epidemiology of oral HPV infections in healthy subjects remains unclear due to a l...

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Autores principales: Gonzalez-Losa, María del Refugio, Barrera, Ernesto Soria, Herrera-Pech, Verónica, Conde-Ferráez, Laura, Puerto-Solís, Marylin, Ayora-Talavera, Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512083/
https://www.ncbi.nlm.nih.gov/pubmed/26221121
http://dx.doi.org/10.1590/S1517-838246120130976
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author Gonzalez-Losa, María del Refugio
Barrera, Ernesto Soria
Herrera-Pech, Verónica
Conde-Ferráez, Laura
Puerto-Solís, Marylin
Ayora-Talavera, Guadalupe
author_facet Gonzalez-Losa, María del Refugio
Barrera, Ernesto Soria
Herrera-Pech, Verónica
Conde-Ferráez, Laura
Puerto-Solís, Marylin
Ayora-Talavera, Guadalupe
author_sort Gonzalez-Losa, María del Refugio
collection PubMed
description High-risk human papillomaviruses (HR-HPV) are considered necessary for the development of cervical cancer. Furthermore, there is no doubt that some types of oral squamous cell carcinoma are associated with HR-HPV. The epidemiology of oral HPV infections in healthy subjects remains unclear due to a lack of knowledge. The objective of this study was to investigate the epidemiology of human papillomavirus infections of the oral mucosa without pathology. A cross-sectional study was performed; samples from 390 women seeking prenatal care, Pap smears, family planning or gynecological diseases were studied. Oral cells were collected by direct swab sampling. Information regarding sociodemographic status, sexual behavior, infectious diseases, contraceptive history and tobacco and alcohol consumption were obtained through direct interviews. HPV and genotypes were detected by type-specific polymerase chain reaction. Our results revealed that 14% of the women studied had an oral HPV infection. Women ≤ 20 years of age had the highest HPV prevalence (24.5%). In total, seven genotypes were identified, including the high-risk genotypes 16, 18, 58 and 59 and the low-risk genotypes 6, 81 and 13, the latter of which is a type exclusive to oral mucosa. Sexual behavior was not associated with the presence of genital HPV types in the oral mucosa. Genital HPV types were present in the oral mucosa of women without associated clinical manifestations; however, sexual behavior was not associated with infection, and therefore others routes of transmission should be explored.
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spelling pubmed-45120832015-07-28 Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico Gonzalez-Losa, María del Refugio Barrera, Ernesto Soria Herrera-Pech, Verónica Conde-Ferráez, Laura Puerto-Solís, Marylin Ayora-Talavera, Guadalupe Braz J Microbiol Genetics and Molecular Microbiology High-risk human papillomaviruses (HR-HPV) are considered necessary for the development of cervical cancer. Furthermore, there is no doubt that some types of oral squamous cell carcinoma are associated with HR-HPV. The epidemiology of oral HPV infections in healthy subjects remains unclear due to a lack of knowledge. The objective of this study was to investigate the epidemiology of human papillomavirus infections of the oral mucosa without pathology. A cross-sectional study was performed; samples from 390 women seeking prenatal care, Pap smears, family planning or gynecological diseases were studied. Oral cells were collected by direct swab sampling. Information regarding sociodemographic status, sexual behavior, infectious diseases, contraceptive history and tobacco and alcohol consumption were obtained through direct interviews. HPV and genotypes were detected by type-specific polymerase chain reaction. Our results revealed that 14% of the women studied had an oral HPV infection. Women ≤ 20 years of age had the highest HPV prevalence (24.5%). In total, seven genotypes were identified, including the high-risk genotypes 16, 18, 58 and 59 and the low-risk genotypes 6, 81 and 13, the latter of which is a type exclusive to oral mucosa. Sexual behavior was not associated with the presence of genital HPV types in the oral mucosa. Genital HPV types were present in the oral mucosa of women without associated clinical manifestations; however, sexual behavior was not associated with infection, and therefore others routes of transmission should be explored. Sociedade Brasileira de Microbiologia 2015-03-31 /pmc/articles/PMC4512083/ /pubmed/26221121 http://dx.doi.org/10.1590/S1517-838246120130976 Text en http://creativecommons.org/licenses/by-nc/3.0/ All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License CC BY-NC.
spellingShingle Genetics and Molecular Microbiology
Gonzalez-Losa, María del Refugio
Barrera, Ernesto Soria
Herrera-Pech, Verónica
Conde-Ferráez, Laura
Puerto-Solís, Marylin
Ayora-Talavera, Guadalupe
Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico
title Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico
title_full Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico
title_fullStr Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico
title_full_unstemmed Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico
title_short Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico
title_sort epidemiology of oral hpv in the oral mucosa in women without signs of oral disease from yucatan, mexico
topic Genetics and Molecular Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512083/
https://www.ncbi.nlm.nih.gov/pubmed/26221121
http://dx.doi.org/10.1590/S1517-838246120130976
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