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DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations

Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary cancer predisposition disorder. In Brazil, the p.R337H TP53 founder mutation causes the variant form of LFS, Li-Fraumeni-like syndrome. The occurrence of cancer and age of disease onset are known to vary, even in patients carrying...

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Detalles Bibliográficos
Autores principales:	Fortes, F.P., Kuasne, H., Marchi, F.A., Miranda, P.M., Rogatto, S.R., Achatz, M.I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Divulgação Científica 2015
Materias:	Biomedical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512099/ https://www.ncbi.nlm.nih.gov/pubmed/25945745 http://dx.doi.org/10.1590/1414-431X20154026

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