Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null-mutation of Ceacam1 impairs hepatic insulin extraction to cause chronic hyperinsulinemia, resulting in insulin resistan...

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Detalles Bibliográficos
Autores principales: Al-Share, Qusai Y., DeAngelis, Anthony M., Lester, Sumona Ghosh, Bowman, Thomas A., Ramakrishnan, Sadeesh K., Abdallah, Simon L., Russo, Lucia, Patel, Payal R., Kaw, Meenakshi K., Raphael, Christian K., Kim, Andrea Jung, Heinrich, Garrett, Lee, Abraham D., Kim, Jason K., Kulkarni, Rohit N., Philbrick, William M., Najjar, Sonia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512217/
https://www.ncbi.nlm.nih.gov/pubmed/25972571
http://dx.doi.org/10.2337/db14-1772

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