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A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction

Successful weight loss is variable for reasons not fully elucidated. Whether effective weight loss results from smaller reductions in energy expenditure during caloric restriction is not known. We analyzed whether obese individuals with a “thrifty” phenotype, that is, greater reductions in 24-h ener...

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Autores principales: Reinhardt, Martin, Thearle, Marie S., Ibrahim, Mostafa, Hohenadel, Maximilian G., Bogardus, Clifton, Krakoff, Jonathan, Votruba, Susanne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512223/
https://www.ncbi.nlm.nih.gov/pubmed/25964395
http://dx.doi.org/10.2337/db14-1881
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author Reinhardt, Martin
Thearle, Marie S.
Ibrahim, Mostafa
Hohenadel, Maximilian G.
Bogardus, Clifton
Krakoff, Jonathan
Votruba, Susanne B.
author_facet Reinhardt, Martin
Thearle, Marie S.
Ibrahim, Mostafa
Hohenadel, Maximilian G.
Bogardus, Clifton
Krakoff, Jonathan
Votruba, Susanne B.
author_sort Reinhardt, Martin
collection PubMed
description Successful weight loss is variable for reasons not fully elucidated. Whether effective weight loss results from smaller reductions in energy expenditure during caloric restriction is not known. We analyzed whether obese individuals with a “thrifty” phenotype, that is, greater reductions in 24-h energy expenditure during fasting and smaller increases with overfeeding, lose less weight during caloric restriction than those with a “spendthrift” phenotype. During a weight-maintaining period, 24-h energy expenditure responses to fasting and 200% overfeeding were measured in a whole-room indirect calorimeter. Volunteers then underwent 6 weeks of 50% caloric restriction. We calculated the daily energy deficit (kilocalories per day) during caloric restriction, incorporating energy intake and waste, energy expenditure, and daily activity. We found that a smaller reduction in 24-h energy expenditure during fasting and a larger response to overfeeding predicted more weight loss over 6 weeks, even after accounting for age, sex, race, and baseline weight, as well as a greater rate of energy deficit accumulation. The success of dietary weight loss efforts is influenced by the energy expenditure response to caloric restriction. Greater decreases in energy expenditure during caloric restriction predict less weight loss, indicating the presence of thrifty and spendthrift phenotypes in obese humans.
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spelling pubmed-45122232016-08-01 A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction Reinhardt, Martin Thearle, Marie S. Ibrahim, Mostafa Hohenadel, Maximilian G. Bogardus, Clifton Krakoff, Jonathan Votruba, Susanne B. Diabetes Obesity Studies Successful weight loss is variable for reasons not fully elucidated. Whether effective weight loss results from smaller reductions in energy expenditure during caloric restriction is not known. We analyzed whether obese individuals with a “thrifty” phenotype, that is, greater reductions in 24-h energy expenditure during fasting and smaller increases with overfeeding, lose less weight during caloric restriction than those with a “spendthrift” phenotype. During a weight-maintaining period, 24-h energy expenditure responses to fasting and 200% overfeeding were measured in a whole-room indirect calorimeter. Volunteers then underwent 6 weeks of 50% caloric restriction. We calculated the daily energy deficit (kilocalories per day) during caloric restriction, incorporating energy intake and waste, energy expenditure, and daily activity. We found that a smaller reduction in 24-h energy expenditure during fasting and a larger response to overfeeding predicted more weight loss over 6 weeks, even after accounting for age, sex, race, and baseline weight, as well as a greater rate of energy deficit accumulation. The success of dietary weight loss efforts is influenced by the energy expenditure response to caloric restriction. Greater decreases in energy expenditure during caloric restriction predict less weight loss, indicating the presence of thrifty and spendthrift phenotypes in obese humans. American Diabetes Association 2015-08 2015-05-11 /pmc/articles/PMC4512223/ /pubmed/25964395 http://dx.doi.org/10.2337/db14-1881 Text en © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
spellingShingle Obesity Studies
Reinhardt, Martin
Thearle, Marie S.
Ibrahim, Mostafa
Hohenadel, Maximilian G.
Bogardus, Clifton
Krakoff, Jonathan
Votruba, Susanne B.
A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
title A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
title_full A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
title_fullStr A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
title_full_unstemmed A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
title_short A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
title_sort human thrifty phenotype associated with less weight loss during caloric restriction
topic Obesity Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512223/
https://www.ncbi.nlm.nih.gov/pubmed/25964395
http://dx.doi.org/10.2337/db14-1881
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