Targeting the Two Oncogenic Functional Sites of the HPV E6 Oncoprotein with a High-Affinity Bivalent Ligand**

The E6 oncoproteins of high-risk mucosal (hrm) human papillomaviruses (HPVs) contain a pocket that captures LxxLL motifs and a C-terminal motif that recruits PDZ domains, with both functions being crucial for HPV-induced oncogenesis. A chimeric protein was built by fusing a PDZ domain and an LxxLL m...

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Detalles Bibliográficos
Autores principales: Ramirez, Juan, Poirson, Juline, Foltz, Clémence, Chebaro, Yassmine, Schrapp, Maxime, Meyer, Amandine, Bonetta, Anaëlle, Forster, Anne, Jacob, Yves, Masson, Murielle, Deryckère, François, Travé, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512291/
https://www.ncbi.nlm.nih.gov/pubmed/26014966
http://dx.doi.org/10.1002/anie.201502646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512291/
https://www.ncbi.nlm.nih.gov/pubmed/26014966
http://dx.doi.org/10.1002/anie.201502646

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