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Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants
Biliary atresia (BA) is an orphan medical condition of the newborn, resulting in end-stage liver cirrhosis due to obliterative cholangiopathy of the extrahepatic bile duct. Although Kasai's hepatoportoenterostomy (KPE) is the well-established first-line therapy, little is known about its surgic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512561/ https://www.ncbi.nlm.nih.gov/pubmed/26240820 http://dx.doi.org/10.1155/2015/383791 |
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author | Madadi-Sanjani, Omid Carl, Nathalie Longerich, Thomas Petersen, Claus Andruszkow, Julia H. K. |
author_facet | Madadi-Sanjani, Omid Carl, Nathalie Longerich, Thomas Petersen, Claus Andruszkow, Julia H. K. |
author_sort | Madadi-Sanjani, Omid |
collection | PubMed |
description | Biliary atresia (BA) is an orphan medical condition of the newborn, resulting in end-stage liver cirrhosis due to obliterative cholangiopathy of the extrahepatic bile duct. Although Kasai's hepatoportoenterostomy (KPE) is the well-established first-line therapy, little is known about its surgical complications. 153 patients receiving open KPE treated at a single center between 1994 and 2014 were analysed retrospectively regarding short-term complications and survival with the native liver. In brief, 40.5% of patients suffered from 1–3 surgical complications, inguinal hernias (IH) being most prevalent (40.0%). In BA patients, incidence of IH was associated with male gender (p = 0.002), the syndromic form of BA (p = 0.038), and percutaneous drainage for ascites (p = 0.002). No association was found with prematurity (p = 0.074) or birth weight (p = 0.912) in our study. In conclusion, IH frequently develops after open KPE of BA patients, but this complication does not negatively affect the patient's outcome. Nevertheless, inspection of the internal inguinal ring and prophylactic closure of inapparent hernias should be discussed in order to prevent secondary surgical procedures. |
format | Online Article Text |
id | pubmed-4512561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45125612015-08-03 Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants Madadi-Sanjani, Omid Carl, Nathalie Longerich, Thomas Petersen, Claus Andruszkow, Julia H. K. Biomed Res Int Research Article Biliary atresia (BA) is an orphan medical condition of the newborn, resulting in end-stage liver cirrhosis due to obliterative cholangiopathy of the extrahepatic bile duct. Although Kasai's hepatoportoenterostomy (KPE) is the well-established first-line therapy, little is known about its surgical complications. 153 patients receiving open KPE treated at a single center between 1994 and 2014 were analysed retrospectively regarding short-term complications and survival with the native liver. In brief, 40.5% of patients suffered from 1–3 surgical complications, inguinal hernias (IH) being most prevalent (40.0%). In BA patients, incidence of IH was associated with male gender (p = 0.002), the syndromic form of BA (p = 0.038), and percutaneous drainage for ascites (p = 0.002). No association was found with prematurity (p = 0.074) or birth weight (p = 0.912) in our study. In conclusion, IH frequently develops after open KPE of BA patients, but this complication does not negatively affect the patient's outcome. Nevertheless, inspection of the internal inguinal ring and prophylactic closure of inapparent hernias should be discussed in order to prevent secondary surgical procedures. Hindawi Publishing Corporation 2015 2015-07-09 /pmc/articles/PMC4512561/ /pubmed/26240820 http://dx.doi.org/10.1155/2015/383791 Text en Copyright © 2015 Omid Madadi-Sanjani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Madadi-Sanjani, Omid Carl, Nathalie Longerich, Thomas Petersen, Claus Andruszkow, Julia H. K. Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants |
title | Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants |
title_full | Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants |
title_fullStr | Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants |
title_full_unstemmed | Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants |
title_short | Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants |
title_sort | inguinal hernias represent the most frequent surgical complication after kasai in biliary atresia infants |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512561/ https://www.ncbi.nlm.nih.gov/pubmed/26240820 http://dx.doi.org/10.1155/2015/383791 |
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