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Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants

Biliary atresia (BA) is an orphan medical condition of the newborn, resulting in end-stage liver cirrhosis due to obliterative cholangiopathy of the extrahepatic bile duct. Although Kasai's hepatoportoenterostomy (KPE) is the well-established first-line therapy, little is known about its surgic...

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Autores principales: Madadi-Sanjani, Omid, Carl, Nathalie, Longerich, Thomas, Petersen, Claus, Andruszkow, Julia H. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512561/
https://www.ncbi.nlm.nih.gov/pubmed/26240820
http://dx.doi.org/10.1155/2015/383791
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author Madadi-Sanjani, Omid
Carl, Nathalie
Longerich, Thomas
Petersen, Claus
Andruszkow, Julia H. K.
author_facet Madadi-Sanjani, Omid
Carl, Nathalie
Longerich, Thomas
Petersen, Claus
Andruszkow, Julia H. K.
author_sort Madadi-Sanjani, Omid
collection PubMed
description Biliary atresia (BA) is an orphan medical condition of the newborn, resulting in end-stage liver cirrhosis due to obliterative cholangiopathy of the extrahepatic bile duct. Although Kasai's hepatoportoenterostomy (KPE) is the well-established first-line therapy, little is known about its surgical complications. 153 patients receiving open KPE treated at a single center between 1994 and 2014 were analysed retrospectively regarding short-term complications and survival with the native liver. In brief, 40.5% of patients suffered from 1–3 surgical complications, inguinal hernias (IH) being most prevalent (40.0%). In BA patients, incidence of IH was associated with male gender (p = 0.002), the syndromic form of BA (p = 0.038), and percutaneous drainage for ascites (p = 0.002). No association was found with prematurity (p = 0.074) or birth weight (p = 0.912) in our study. In conclusion, IH frequently develops after open KPE of BA patients, but this complication does not negatively affect the patient's outcome. Nevertheless, inspection of the internal inguinal ring and prophylactic closure of inapparent hernias should be discussed in order to prevent secondary surgical procedures.
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spelling pubmed-45125612015-08-03 Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants Madadi-Sanjani, Omid Carl, Nathalie Longerich, Thomas Petersen, Claus Andruszkow, Julia H. K. Biomed Res Int Research Article Biliary atresia (BA) is an orphan medical condition of the newborn, resulting in end-stage liver cirrhosis due to obliterative cholangiopathy of the extrahepatic bile duct. Although Kasai's hepatoportoenterostomy (KPE) is the well-established first-line therapy, little is known about its surgical complications. 153 patients receiving open KPE treated at a single center between 1994 and 2014 were analysed retrospectively regarding short-term complications and survival with the native liver. In brief, 40.5% of patients suffered from 1–3 surgical complications, inguinal hernias (IH) being most prevalent (40.0%). In BA patients, incidence of IH was associated with male gender (p = 0.002), the syndromic form of BA (p = 0.038), and percutaneous drainage for ascites (p = 0.002). No association was found with prematurity (p = 0.074) or birth weight (p = 0.912) in our study. In conclusion, IH frequently develops after open KPE of BA patients, but this complication does not negatively affect the patient's outcome. Nevertheless, inspection of the internal inguinal ring and prophylactic closure of inapparent hernias should be discussed in order to prevent secondary surgical procedures. Hindawi Publishing Corporation 2015 2015-07-09 /pmc/articles/PMC4512561/ /pubmed/26240820 http://dx.doi.org/10.1155/2015/383791 Text en Copyright © 2015 Omid Madadi-Sanjani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Madadi-Sanjani, Omid
Carl, Nathalie
Longerich, Thomas
Petersen, Claus
Andruszkow, Julia H. K.
Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants
title Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants
title_full Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants
title_fullStr Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants
title_full_unstemmed Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants
title_short Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants
title_sort inguinal hernias represent the most frequent surgical complication after kasai in biliary atresia infants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512561/
https://www.ncbi.nlm.nih.gov/pubmed/26240820
http://dx.doi.org/10.1155/2015/383791
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