Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

Impaired immune responses in the elderly lead to reduced vaccine efficacy and increased susceptibility to viral infections. Although several groups have documented age-dependent defects in adaptive immune priming, the deficits that occur prior to antigen encounter remain largely unexplored. Herein,...

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Detalles Bibliográficos
Autores principales: Richner, Justin M., Gmyrek, Grzegorz B., Govero, Jennifer, Tu, Yizheng, van der Windt, Gerritje J. W., Metcalf, Talibah U., Haddad, Elias K., Textor, Johannes, Miller, Mark J., Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512688/
https://www.ncbi.nlm.nih.gov/pubmed/26204259
http://dx.doi.org/10.1371/journal.ppat.1005027

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