Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats

BACKGROUND: The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase...

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Detalles Bibliográficos
Autores principales: Almac, Emre, Bezemer, Rick, Kandil, Asli, Aksu, Ugur, Milstein, Dan MJ, Bakker, Jan, Demirci-Tansel, Cihan, Ince, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512971/
https://www.ncbi.nlm.nih.gov/pubmed/26266905
http://dx.doi.org/10.1186/2197-425X-2-3
Descripción
Sumario:BACKGROUND: The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase of reperfusion (up to 90 min post-ischemia). METHODS: Ischemia was established in anesthetized and mechanically ventilated male Wistar rats by renal artery clamping. Renal microvascular and venous oxygenation were measured using phosphorimetry. Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function. RESULTS: The main findings were that BMOV did not affect the systemic and renal hemodynamic and oxygenation variables and partially protected renal sodium reabsorption. CONCLUSIONS: Pretreatment with the organic vanadium compound BMOV did not protect the kidney from I/R injury.

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