Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury

BACKGROUND: Mechanical stress induced by injurious ventilation leads to pro-inflammatory cytokine production and lung injury. The extracellular-signal-regulated-kinase, ERK1/2, participates in the signaling pathways activated upon mechanical stress in the lungs to promote the inflammatory response....

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Detalles Bibliográficos
Autores principales: Kaniaris, Evangelos, Vaporidi, Katerina, Vergadi, Eleni, Theodorakis, Emmanuel E, Kondili, Eumorfia, Lagoudaki, Eleni, Tsatsanis, Christos, Georgopoulos, Dimitris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513004/
https://www.ncbi.nlm.nih.gov/pubmed/26266915
http://dx.doi.org/10.1186/2197-425X-2-15

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