Relationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence

BACKGROUND AND OBJECTIVE: Circadian rhythms may influence the pharmacokinetics of drugs. This study aimed to elucidate whether the pharmacokinetics of the orally administered drug sunitinib are subject to circadian variation. METHODS: We performed studies in male FVB-mice aged 8–12 weeks, treated wi...

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Detalles Bibliográficos
Autores principales: Kloth, Jacqueline S. L., Binkhorst, Lisette, de Wit, Annelieke S., de Bruijn, Peter, Hamberg, Paul, Lam, Mei H., Burger, Herman, Chaves, Ines, Wiemer, Erik A. C., van der Horst, Gijsbertus T. J., Mathijssen, Ron H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513224/
https://www.ncbi.nlm.nih.gov/pubmed/25647628
http://dx.doi.org/10.1007/s40262-015-0239-5

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