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The role of triterpenes in the management of diabetes mellitus and its complications
Diabetes mellitus is a chronic metabolic disease which is a serious global problem. In 2010 an estimated 285 million people had diabetes and within the next 20 years this value is expected to almost double. Many antidiabetic therapies focus on improving insulin sensitivity, increasing insulin produc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513225/ https://www.ncbi.nlm.nih.gov/pubmed/26213526 http://dx.doi.org/10.1007/s11101-014-9369-x |
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author | Nazaruk, J. Borzym-Kluczyk, M. |
author_facet | Nazaruk, J. Borzym-Kluczyk, M. |
author_sort | Nazaruk, J. |
collection | PubMed |
description | Diabetes mellitus is a chronic metabolic disease which is a serious global problem. In 2010 an estimated 285 million people had diabetes and within the next 20 years this value is expected to almost double. Many antidiabetic therapies focus on improving insulin sensitivity, increasing insulin production, and/or decreasing the level of blood glucose. Although a number of synthetic medicines are available, drugs of natural origin have aroused great interest. Triterpenes seem to demonstrate adequate properties. Many experiments have shown that these compounds have several antidiabetic mechanisms. They can inhibit enzymes involved in glucose metabolism, prevent the development of insulin resistance and normalize plasma glucose and insulin levels. These natural compounds, in contrast to synthetic drugs, apart from producing a hypoglycemic effect have also been found to manifest hypolipidemic and anti-obesity activity. Triterpenes are also promising agents in the prevention of diabetic complications. They have strong antioxidant activity and inhibit the formation of advanced glycation end products, implicated in the pathogenesis of diabetic nephropathy, embryopathy, neuropathy or impaired wound healing. Until now very few clinical studies have been concerned with the application of triterpenes in treating diabetes. However, due to their great therapeutic potential, these compounds deserve special attention. |
format | Online Article Text |
id | pubmed-4513225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-45132252015-07-24 The role of triterpenes in the management of diabetes mellitus and its complications Nazaruk, J. Borzym-Kluczyk, M. Phytochem Rev Article Diabetes mellitus is a chronic metabolic disease which is a serious global problem. In 2010 an estimated 285 million people had diabetes and within the next 20 years this value is expected to almost double. Many antidiabetic therapies focus on improving insulin sensitivity, increasing insulin production, and/or decreasing the level of blood glucose. Although a number of synthetic medicines are available, drugs of natural origin have aroused great interest. Triterpenes seem to demonstrate adequate properties. Many experiments have shown that these compounds have several antidiabetic mechanisms. They can inhibit enzymes involved in glucose metabolism, prevent the development of insulin resistance and normalize plasma glucose and insulin levels. These natural compounds, in contrast to synthetic drugs, apart from producing a hypoglycemic effect have also been found to manifest hypolipidemic and anti-obesity activity. Triterpenes are also promising agents in the prevention of diabetic complications. They have strong antioxidant activity and inhibit the formation of advanced glycation end products, implicated in the pathogenesis of diabetic nephropathy, embryopathy, neuropathy or impaired wound healing. Until now very few clinical studies have been concerned with the application of triterpenes in treating diabetes. However, due to their great therapeutic potential, these compounds deserve special attention. Springer Netherlands 2014-06-24 2015 /pmc/articles/PMC4513225/ /pubmed/26213526 http://dx.doi.org/10.1007/s11101-014-9369-x Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article Nazaruk, J. Borzym-Kluczyk, M. The role of triterpenes in the management of diabetes mellitus and its complications |
title | The role of triterpenes in the management of diabetes mellitus and its complications |
title_full | The role of triterpenes in the management of diabetes mellitus and its complications |
title_fullStr | The role of triterpenes in the management of diabetes mellitus and its complications |
title_full_unstemmed | The role of triterpenes in the management of diabetes mellitus and its complications |
title_short | The role of triterpenes in the management of diabetes mellitus and its complications |
title_sort | role of triterpenes in the management of diabetes mellitus and its complications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513225/ https://www.ncbi.nlm.nih.gov/pubmed/26213526 http://dx.doi.org/10.1007/s11101-014-9369-x |
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