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Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery
Although alginate hydrogels have been extensively studied for tissue engineering applications, their utilization is limited by poor mechanical strength, rapid drug release, and a lack of cell adhesive ability. Aiming to improve these properties, we employ the interpenetrating hydrogel design rationa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513302/ https://www.ncbi.nlm.nih.gov/pubmed/26205586 http://dx.doi.org/10.1038/srep12374 |
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author | Zhang, Yeshun Liu, Jia Huang, Lei Wang, Zheng Wang, Lin |
author_facet | Zhang, Yeshun Liu, Jia Huang, Lei Wang, Zheng Wang, Lin |
author_sort | Zhang, Yeshun |
collection | PubMed |
description | Although alginate hydrogels have been extensively studied for tissue engineering applications, their utilization is limited by poor mechanical strength, rapid drug release, and a lack of cell adhesive ability. Aiming to improve these properties, we employ the interpenetrating hydrogel design rationale. Using alginate and sericin (a natural protein with many unique properties and a major component of silkworm silk), we develop an interpenetrating polymer network (IPN) hydrogel comprising interwoven sericin and alginate double networks. By adjusting the sericin-to-alginate ratios, IPNs’ mechanical strength can be adjusted to meet stiffness requirements for various tissue repairs. The IPNs with high sericin content show increased stability during degradation, avoiding pure alginate’s early collapse. These IPNs have high swelling ratios, benefiting various applications such as drug delivery. The IPNs sustain controlled drug release with the adjustable rates. Furthermore, these IPNs are adhesive to cells, supporting cell proliferation, long-term survival and migration. Notably, the IPNs inherit sericin’s photoluminescent property, enabling bioimaging in vivo. Together, our study indicates that the sericin-alginate IPN hydrogels may serve as a versatile platform for delivering cells and drugs, and suggests that sericin may be a building block broadly applicable for generating IPN networks with other biomaterials for diverse tissue engineering applications. |
format | Online Article Text |
id | pubmed-4513302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45133022015-07-29 Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery Zhang, Yeshun Liu, Jia Huang, Lei Wang, Zheng Wang, Lin Sci Rep Article Although alginate hydrogels have been extensively studied for tissue engineering applications, their utilization is limited by poor mechanical strength, rapid drug release, and a lack of cell adhesive ability. Aiming to improve these properties, we employ the interpenetrating hydrogel design rationale. Using alginate and sericin (a natural protein with many unique properties and a major component of silkworm silk), we develop an interpenetrating polymer network (IPN) hydrogel comprising interwoven sericin and alginate double networks. By adjusting the sericin-to-alginate ratios, IPNs’ mechanical strength can be adjusted to meet stiffness requirements for various tissue repairs. The IPNs with high sericin content show increased stability during degradation, avoiding pure alginate’s early collapse. These IPNs have high swelling ratios, benefiting various applications such as drug delivery. The IPNs sustain controlled drug release with the adjustable rates. Furthermore, these IPNs are adhesive to cells, supporting cell proliferation, long-term survival and migration. Notably, the IPNs inherit sericin’s photoluminescent property, enabling bioimaging in vivo. Together, our study indicates that the sericin-alginate IPN hydrogels may serve as a versatile platform for delivering cells and drugs, and suggests that sericin may be a building block broadly applicable for generating IPN networks with other biomaterials for diverse tissue engineering applications. Nature Publishing Group 2015-07-24 /pmc/articles/PMC4513302/ /pubmed/26205586 http://dx.doi.org/10.1038/srep12374 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Zhang, Yeshun Liu, Jia Huang, Lei Wang, Zheng Wang, Lin Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery |
title | Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery |
title_full | Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery |
title_fullStr | Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery |
title_full_unstemmed | Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery |
title_short | Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery |
title_sort | design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513302/ https://www.ncbi.nlm.nih.gov/pubmed/26205586 http://dx.doi.org/10.1038/srep12374 |
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